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  • PostDoc
13 February 2021

PhD and Postdoc Positions CEITEC Masaryk University, Czec

PhD positions at the CEITEC Masaryk University, Czec                                         

Starting:      September 2021
Duration:     4 years
Expires:        Applications are considered until the position is filled
Supervisor: Robert Vacha (robert.vacha@mail.muni.cz)
Employer:   CEITEC Masaryk University, Czech Rep.


Postdoc positions

Starting:      April 2021 or later
Duration:     2 years
Expires:        Applications are considered until the position is filled
Supervisor: Robert Vacha (robert.vacha@mail.muni.cz)
Employer:   CEITEC Masaryk University, Czech Rep.

For further information:
http://vacha.ceitec.cz/jobs-openings/

1) Selectivity of translocation across lipid membranes

We have shown that a specific class of transmembrane proteins, called scramblases, can facilitate not only spontaneous flip-flop of lipids but also a translocation of other amphiphilic molecules across cellular membranes. However, we miss information about the selectivity of this transport. The goal of this project is to determine the specificity of scramblase activity and obtain a molecular understanding of the selectivity. The main tool will be Molecular dynamics simulations with free energy calculations.

2) Synergistic translocation of multiple peptides

Translocation of peptides across cell membranes is one of the mechanisms by which antimicrobial peptides can kill bacteria. Moreover, such peptides can act as cell-penetrating peptides delivering drug cargos to the cell. Despite the potential of such peptides, their development is hindered by the lack of knowledge about the peptide sequence-to-function relationship. In this project, we will take advantage of peptide synergism, in which peptide mixture is more effective than its components. In particular, the project is focused on the co-translocation of multiple peptides. The main tool will be Molecular dynamics simulations with free energy calculations. Part of the project could take advantage of Monte Carlo simulations with a highly coarse-grained model.

3) Association of proteins in phospholipid membranes

A large fraction of membrane proteins forms oligomers. These include receptors, ion channels, and fusion proteins, which association and dissociation control essential cellular processes. In the past, the membrane was viewed as a passive environment, in which the association takes place. Now we know that lipids can play an active role in determining the change of the oligomerization state. However, the interplay between the lipids and protein oligomerization state remains poorly understood. The goal of this project is to calculate the association of selected membrane proteins in the environments of various lipid compositions and determine the key features controlling the oligomerization state. We will do so by Molecular dynamics simulations with free energy calculations.

Eligibility: Outstanding candidates with experience in computer simulations and with an MSc/PhD degree in the fields of biophysics, soft matter physics, physical chemistry, computational chemistry, statistical mechanics, or related fields. Experience with molecular dynamics simulations (with GROMACS, CHARMM, NAMD, AMBER, LAMMPS, etc.) or other simulation techniques (Monte Carlo, DPD, etc.) at the atomistic or coarse-grained level would be an advantage.

Computing Resources: Successful candidates will have access to local computing clusters with 2500 cores and 100 GPUs. Access to Metacentrum NGI – National Grid Infrastructure for computing (with ~20,000 cores) will be also available. Additional resources include the possibility of applying for IT4Inovations, where the group is active.

Competitive salary: depending on the position - supported by grant projects including ERC consolidator grant.

Application procedure: Applications must include a CV, with list of publications and study results, short personal statement (description of research interests, past, and plans), and the name of a person willing to provide a letter of recommendation. Applications with all this material (preferably in a single pdf) should be sent to Robert Vacha (robert.vacha@mail.muni.cz).
Why join us?

    International opportunities – CEITEC is a leading member of Alliance 4 Life, a member of the EU Life consortium, in strategic partnership with The Vienna Biocenter Core Facilities
    Wide career options
    Build connections via our international partnerships and events (47% of publications created within the international cooperation)
    Transferable skills courses, cooperation with industry
    Brno is EU & NATO member and voted 4th best city for students’ life
    An international community with frequent informal events
    Top score in Quality of life index in 2020

Institute:

CEITEC is a scientific centre in the fields of life sciences, advanced materials and technologies whose aim is to establish itself as a recognized centre for basic as well as applied research. CEITEC offers a state-of-the-art infrastructure and great conditions to employ excellent researchers. Our institute values diversity and promotes an inclusive working environment with the aim to support the best scientists. CEITEC MU is a proud holder of the HR Excellence in Research Award by the European Commission.

Go to announcement
    13 February 2021

    Scientific User Support Engineer, Vienna

    HPS team working on cloud infrastructure                                                                                                             

     

    We are looking for a new colleague to strengthen our HPC team working on the Cloud Infrastructure Platform (CLIP) / Wir suchen Verstärkung für unser HPC-Team auf der Cloud
    Infrastructure Platform (CLIP):

    https://www.karriere.at/jobs/5789754
    <https://www.karriere.at/jobs/5789754>

     

    The Institute of High Energy Physics (HEPHY) of the Austrian Academy of Sciences (OeAW), Austria’s leading non-university institution for science and research, is offering a position as
    SCIENTIFIC USER SUPPORT ENGINEER (F*M)

    (full-time / 40h per week)

    The Institute participates in large research collaborations, such as CMS at the Large Hadron Collider at CERN and Belle II at SuperKeKB in Japan. These collaborations cover a broad range of experiments, ranging from the study of the Higgs Boson to the search for new phenomena, such as Dark Matter. To facilitate the research, the Institute is a member of the worldwide LCG computing grid. In collaboration with life science institutes in Vienna, we have established an interdisciplinary HPC infrastructure with scientific applications in domains as diverse as, e.g., life science, particle physics, materials science, space research, acoustics research, or archaeology. We are looking for a user support engineer to strengthen our HPC team. You will work in a dynamic, international, and technically challenging environment where you will interact with scientists, software engineers and fellow DevOps engineers.

    Your main tasks:

        Provide the first line of contact for user requests
        Provide software installation and deployment support in a wide variety of programming languages
        Solve HPC scheduler issues (SLURM)
        Train users in Linux usage

    Your profile:

        Demonstrable experience working in an HPC or larger Linux production environment
        An open and curious attitude to learning and applying new technologies is a must. Work both independently and as a team member and must be fluent in English, both speaking and writing.
        Knowledge of German would be advantageous.
        Linux basics (Shell, file systems, syscalls, …)
        Basic knowledge of specific development environments and usual installation procedures for Python (anaconda, setup tools, etc.), R, GNU Autotools, make/CMake, …
        Service-oriented, Sociable and the Ability to work within a team

    Technical skills nice-to-have:

        Experience in software development (Python/C/C++/Java/…) and as a system engineer (Ansible, …)
        Knowledge in the field of cloud computing and cloud architecture
        Experience with Big Data application frameworks and with Linux Container run times (Docker, Singularity, etc.)

    We offer an annual gross salary of € 40.897,92, according to the collective agreement of the Austrian Academy of Sciences (OeAW). Depending on qualification and experience the salary can be negotiated. The position is limited until December 31, 2025.

    For further information, please contact Dr. Felix Schmitt (felix.schmitt@oeaw.ac.at). Please send your application via email to Bewerbung@oeaw.ac.at (mentioning Job ID: HEPHY011TEC221) no later than February 28, 2021.

    The Austrian Academy of Sciences (OeAW) pursues a non-discriminatory employment policy and values equal opportunities, as well as diversity. The OeAW lays special emphasis on increasing the number of women in senior and in academic positions. Given equal qualifications, preference will be given to female applicants.

    Go to announcement
    • Postdoctoral Fellow Position in Liverpool
    13 February 2021

    5 PhD Fellowships in Physics and Chemisty,, Trieste Italy

    International School for Advanced Studies, Trieste                                                                            

    There are 5 positions available for the PhD in "Physics and Chemistry of Biological Systems" at the International School for Advanced Studies (SISSA), Trieste, Italy.

    The application deadline is March 16, 2021, for both EU and non EU students

    Students are expected to join the written and oral exam on March 29 and 30. The exam will be held remotely.

    Applicants should have a good background in Physics, Chemistry, Applied Mathematics or related subjects and are expected to obtain their Laurea Specialistica or equivalent degree by Autumn 2021.

    The application can be done online at this link:
    https://pica.cineca.it/sissa/phd-physchem-01-2021/

    Admitted students will have the opportunity to follow a one-year educational program in an international and interdisciplinary environment, followed by three years of active research in one of the following areas:

        Structural bioinformatics
        Statistical mechanics of complex molecular systems
        Biomolecular simulations
        Simulations of rare events
        Data science of complex and biomolecular systems
        Polymer physics
        Active matter

    For further information about the available research lines and past entrance exams see:
    http://www.sissa.it/sbp/phdsection/entranceexam.php
    and related webpages.

    Go to announcement
    • PostDoc
    13 February 2021

    2 PostDoc Positions, Linz, Austria

    Two PostDoc Positions
    in single-molecule microscopy

    The world is changing at an ever-faster pace. At the Johannes Kepler University Linz, we work on technologies and the ideas of tomorrow on a daily basis. At the same time, we educate over 21,000 young people to meet the demands of today’s job market. In short, we are Upper Austria’s largest institution for education and research. Are you interested in being a part of shaping the future of Austria’s most attractive campus university? We currently have two immediate job openings for:
    PostDocs (must hold a Doctorate/Ph.D. degree)
    (i) for a full-time, six-year position
    (ii) for a full time, 20 months position
    at the Institute of Biophysics, Department of Molecular and Membrane Biophysics

    Job Duties:
    • Research: Contribute to research activities and publications within the Pohl group’s research foci
    • Education: Assist in teaching university-level courses offered by the institute (mandatory only for the 6 year-position)
    Your Qualifications:
    • The successful candidate must hold a Doctorate/Ph.D. in the field of Physics/Biophysics or equivalent qualification
    • Strong command of English (level C1)
    • Expertise in a programming language
    • Experience in setup and application of highly-sensitive light microscopic techniques, preferably fluorescence
    single-molecule microscopy
    • Knowledge of fluorescence correlation spectroscopy is desirable
    • Working experiences with planar and vesicular model membranes and in electrophysiology are advantageous
    • Commitment, responsibility, communication and critical thinking skills, team spirit and ambition
    What We Offer:
    • On the basis of full-time employment (40 hours/week) the minimum salary in accordance with the collective agreement is € 3,945.90 gross per month (14 x per year, CA Job Grade: B1)
    • Stable employer
    • Attractive campus environment with good public transportation connections
    • Attractive continual educational opportunities
    • State-of-the-art research infrastructure
    • Dynamic research environment
    • Broad range of on-campus dining services/healthy meals (organic food at the cafeteria)
    • Exercise and sports classes (USI)
    • …and much more
    Application Deadline: February 10, 2021.
    The Johannes Kepler University wishes to increase the proportion of academic female faculty and, for this reason, especially welcomes applications by qualified women. If applicants are equally qualified, a woman will be given preference for this position. The university welcomes applications from qualified applicants with physical disabilities. These applications will be given special consideration.
    How to Apply:
    Prospective applicants interested in the multifaceted position are requested to electronically send an application in adherence to the stated criteria together with the requested documentation via our online portal jku.at/application or to the Johannes Kepler University Linz, Department of Human Resource Management, Altenberger Straße 69, A-4040 Linz. Please include “Job Reference Number 4411“ in your application.
    Contact:
    If you have questions, please contact: Univ. Prof. Dr. Peter Pohl, P +43 732 2468 7562, E mail: peter.pohl@jku.at.

    Go to announcement
    • PhD
    13 February 2021

    Research Associate at Liège

    Facility manager at the University of LiègeThe  Centre  for  Protein  Engineering  (CIP)  at  the  Université  de  Liège  is offering  a positionfor  a research  associate  in  the  fields  of  biochemistry,  molecular  biologyand biotechnology.  He  or  she  will  be  the  manager  of  the  Robotein®facility  (Liège  site)(http://www.robotein.ulg.ac.be/), which is dedicated to high-throughput protein production and analysis. This  platform,  which  has  recently  been  added  to the  Instruct-ERIC  catalogue(https://instruct-eric.eu/centres/instruct-be/), offers    automated    screening    for    optimal recombinant protein expression, purification and formulation, together with biochemical and biophysical protein analysis.The position is initially for one year and is based in the Department of Life Sciences and the InBioS research unit, in the Faculty of Sciences.It offers opportunities for  scientific  collaboration  at  the  national  and  international  level,  both  with  academic  and industrial partners, and enables an ambitious candidate to play an important role in the shaping of the future development of the facility as a flagship of the Institution. Agood  knowledge  and  technical  expertise  in  the  fields  of  protein  production  and analysis, with particular emphasis on protein-ligand interactions, are expected.The candidatewill play  an  important  rolein  the  development  of  existing  or  new  protocols  for  the characterization of proteins. Furthermore, the applicant willalsobe expected to demonstrate managerial skills, including meetings with collaborators or clients,hosting of Instruct-ERIC visitors,administrative  duties,  maintenanceand  accountingwork,and  organisational management. Applicants need to be confident in developing new technological tools for the advancement of Robotein®, in particular within the frame of its new partnership with Instruct-ERIC, which aimsatfacilitating important scientific breakthroughs.Theposition offersan  exciting  opportunity  to  make  a  major  contribution  to  the development ofaninternationallyacknowledgedplatform,while allowing you to progress and enxpandyour scientific knowledge and network.Contact:  Professor  André  Matagne  (amatagne@ulg.ac.be),  coordinator  of  Robotein®and chair of the Centre for Protein Engineering

    Go to announcement
      13 February 2021

      Senior NMR technical Position

      Senior NMR technical Position Australia                                                                                                                                                        

      A senior NMR technical position is available to operate the magnetic resonance facility at the Australian National University (ANU) in Canberra.  The facility houses NMR spectrometers (400, 600, 700 and 800 MHz; cryoprobes at 600 and 800 MHz; fast MAS solid-state probes at 700 and 800 MHz) and pulsed EPR (X-band, Q-band, W-band) equipment. It is located in the Research School of Chemistry (RSC) and serves the entire university.

      You will work directly with protein researchers, material scientists and synthetic chemists. Your responsibilities will include the operation and maintenance of the equipment, as well as the implementation of NMR methods and training of users in NMR. The position requires a Ph.D. in chemistry, biochemistry, physics or closely related field. Excellent communication skills are required.

      The successful applicant must have rights to live and work in Australia.

      Queries can be addressed to

      Professor Gottfried Otting

      The Australian National University

      Research School of Chemistry

      Sullivans Creek Rd, Bldg 137

      Canberra ACT 2601, Australia

      phone: +61-2-6125 6507

      email: gottfried.otting@anu.edu.au

      http://rsc.anu.edu.au/~go/index.html

      Go to announcement
      • Assistant Professor in Biophysics, Japan
      11 January 2021

      Universitätsassistent/in TU Graz

      Institut für Biotechnologie und Bioprozesstechnik TU Graz                                  

      Am Institut für Biotechnologie und Bioprozesstechnik der Technischen Universität Graz ist folgendeStelle ausgeschrieben:1 Stelle eines/einer Universitätsassistent*in, Ersatzkraft, 40 Stunden/Woche, voraussichtlich ab 1. März 2021, am Institut für Biotechnologie und Bioprozesstechnik.

      Aufgaben der Position:-Mitwirkung bei der Betreuung von B.Sc., M.Sc. Arbeiten und Diplomarbeiten-Betreuung von LV (LU)-selbstständige, wissenschaftliche Forschung-Mitarbeit an Forschungsprojekten

      Aufnahmebedingungen:Abgeschlossenes Master-bzw. Diplomstudium.Vorausgesetzte Studienrichtungen:Abgeschlossenes Masterstudium der Biotechnologie oder Abschluss eines vergleichbaren Studiums.

      Gewünschte Qualifikationen:-Spezialisierung im Zuge des Studiums auf die Fächer Biotechnologie und Bioprozesstechnik-Kenntnis der Methoden der mikrobiellen Biotechnologie-Erfahrung mit dem Einsatz von bildgebenden Verfahren im Bereich der Biotechnologie.Einstufung:B 1 nach Kollektivvertrag für die Arbeitnehmer*innen der Universitäten; das monatliche Mindestentgelt für diese Verwendung beträgt derzeit € 2.971,50 brutto (14× jährlich) und kann sich eventuell auf Basis der kollektivvertraglichen Vorschriften durch die Anrechnung tätigkeitsspezifischer Vorerfahrungen sowie sonstige mit den Besonderheiten des Arbeitsplatzes verbundene Entgeltbestandteile erhöhen.

      Ende der Bewerbungsfrist: 28. Jänner 2021

      Kennzahl:6510/21/002
      Kontakt: Bewerbung, Lebenslauf und weitere Unterlagen sind unter genauer Bezeichnung der Stelle bzw. der Kennzahl an die Technische Universität Graz, Dekan der Fakultät für Technische Chemie, Verfahrenstechnik und Biotechnologie, Univ.-Prof. Dipl.-Chem. Dr.rer.nat. Frank Uhlig, (vorzugsweise elektronisch an jobs.tcvb@tugraz.at) zu richten und müssen bis spätestens Ende der Bewerbungsfrist einlangen.

      Go to announcement
        11 January 2021

        Senior Scientist Cambridge, UK

        We are looking for a Senior Scientist or Scientist highly experienced in protein structural analysis with emphasis on homology modelling and structure-based protein design. Strong understanding of molecular interactions is essential.

        To apply:
        https://www.lonza.com/jobs/R28003

        Daphné Truan, PhD
        Bioinformatics Group Leader
        Gonville Building (B200)
        Chesterford Research Park
        CB10 1XL Cambridge
        United Kingdom
        www.lonza.com

        Go to announcement
          11 January 2021

          Senior Scientist, Slough, UK

          We are seeking an exceptional candidate to join our Computer-Aided Drug Design (CADD) team within Global CADD to drive the discovery of new therapeutic candidates and further build our targeted protein degradation platform.

          This position can be located either in our UK research site in Slough, our Belgian research site in Braine-l'Alleud or our US research site in Bedford, MA, USA.

          https://careers.ucb.com/job/Slough-Senior-Scientist-Berk/637501601/

          Go to announcement
            29 September 2020

            PhD Student or Postdoc (f/m/d)

            The Max Planck Institute for Biophysical Chemistry

            is one of the largest institutes of the Max Planck Society for the Advancement of Science and conducts basic research to advance knowledge and benefit society. Innovative projects and interdisciplinary cooperation characterize research within the Max Planck Society. The Department of Theoretical and Computational Biophysics (Prof. Dr. Helmut Grubmüller) invites applications for a position as

            PhD Student or Postdoc (f/m/d) (Code number 19-20) for the projects – Ribosomal Translation: Molecular Mechanisms and Antibiotics – – Statistical Mechanics and Function of Intrinsically Disordered Proteins – – Optimal Free Energy and Entropy Calculations – – Markovian Free Energy Models of F-ATP Synthase Function – – Fast Multipole Based Constant pH Methods –

            The successful candidate for either position has a keen interest and strong skills in computational biomolecular physics, skills in structural biology, statistical mechanics, and scientific computing, and a strong interest in interdisciplinary research and collaboration with experimental groups. PhD candidates hold (or expect to complete soon) a Masters or equivalent degree; Postdocs hold a PhD or equivalent degree in any of these or a related field. PhD students will have the opportunity to participate in one of several available PhD programs, with four years funding, in collaboration with the University of Göttingen. Masters students aiming at a fast track PhD are also welcome. The Postdoc position is limited to two years with a possibility of extension. Payment and benefits are based on the TVöD guidelines. The starting date is flexible. The group language is English, so no German language skills are required – but it’s a great opportunity for you to learn German!

            The Max Planck Society is committed to increasing the number of individuals with disabilities in its workforce and therefore encourages applications from such qualified individuals.

            Interested? Submit your application including cover letter (explaining background and motivation), CV, transcripts, and publication record preferably via e-mail as one single PDF file to

            ausschreibung19-20@mpibpc.mpg.de
            Max Planck Institute for Biophysical Chemistry
            Department „Theoretical and Computational Biophysics“
            Prof. Dr. Helmut Grubmüller
            Am Fassberg 11
            37077 Göttingen Germany
            Web: https://www.mpibpc.mpg.de/grubmueller

             

            Go to announcement

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