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  • PhD

21.09.2020

21 September 2020

Early Stage Researcher Training PhD

An Early Stage Researcher (PGR studentship) within the MSCA-ITN-ETN NeuroTrans 
 
The European Training Network (ETN) NeuroTrans (NEUROtransmitter TRANSporters: From single molecules to human pathologies) announces 15 PhD candidate positions for Early-Stage Researchers (ESRs) with the option of being awarded a doctoral degree. NeuroTrans is an Innovative Training Networks (ITN) from the Marie Skłodowska-Curie Actions Programme, funded by the European Commission under the framework of Horizon 2020. The NeuroTrans ETN (Grant number 860954) will establish an international training programme by forming a highly interdisciplinary team of world-leading European researchers from 9 universities and 5 industrial partners. NeuroTrans makes ample use of existing cutting-edge methods to reach this goal, but also develops enabling techniques in biophysics, molecular and structural biology.
 
The vision of the NeuroTrans project is:
 
•    to reach a comprehensive understanding of neurotransmitter:sodium symporter (NSS) function ranging from the molecular level to human pathologies;
•    to investigate how psychoactive substances target these transporters;
•    to elucidate how disruption of transporter function contributes to neuropsychiatric disease pathobiology.
 
To accomplish our vision, NeuroTrans will establish an interdisciplinary training school that includes most important subdisciplines in quantitative biology, including molecular modelling, computer simulations, biophysics, biochemistry, neurobiology, human pathology, molecular and structural biology, but also engineering and programming. Through the training offered by NeuroTrans, PhD candidates will develop a cutting edge set of skills ranging from computer simulations to membrane protein structural biology, dynamics and thermodynamics to human diseases, pathologies and instrument development. By integration of the industrial sector in the training, NeuroTrans will offer training in entrepreneurship, product development and commercialisation to prepare the NeuroTrans students for acquiring leading positions in academia and industry.
 
Details on the NeuroTrans programme and the recruitment can be found on the NeuroTrans homepage. The positions are available at 9 universities and 3 companies in 8 different European countries. Employment is according to the regulations by the hosting university or company and the rules of the Marie Sklodowska-Curie Actions. All Marie Skłodowska-Curie Actions funded ESR position positions are limited to a duration of 36 months, but can be extended according to national regulations. The PhD candidate will enroll in a university PhD programme.
 
The PhD candidate must have a first degree in a Chemistry, Biochemistry, Biophysics, Physics, or a related field (equivalent to 2:1 or better 1st class classification), and be able to meet all the essential criteria in the Person Specification.
 
EU applicants are eligible to apply who have not been based in the UK for more than 12 months in the last 3 years.
 
The successful candidates will receive a 36-month, full-time employment contract as per Marie Skłodowska-Curie Actions (MSCA) regulations for Early Stage Researchers (ESRs). The gross salary is comprised of the following three standard EU allowances:
 
The gross salary is comprised of the following three standard EU allowances:
Living allowance    Monthly allowance    Family allowance
€ 3270    € 600    € 500

Living Allowance
The PhD candidates will be employed with employment contracts. The monthly living allowance is subject to deductions of employer’s and employee’s contributions to National Insurance, income tax, etc. This amount is then adjusted through the multiplication with the country correction coefficient (Austria=1.067; Denmark=1.350; France=1.157; Germany=0.970; Italy=1.044; Portugal=0.842; The Netherlands=1.079; United Kingdom=1.398) to the living allowance of the country in which the PhD candidate will be recruited, reflecting the average difference is living cost between EU countries.
 
Monthly Allowance
All eligible PhD candidates recruited within NeuroTrans are entitled to receive this gross allowance. It contributes to the mobility related expenses.
 
The School is an equal opportunities employer and we welcome all applicants, regardless of age, disability, ethnicity, gender, nationality, race, religion or sexual orientation. All appointments are made on merit. Our policies and practices are designed to encourage talented people, whatever their background, to work and study here. Work-life balance, family friendly policies and staff benefits are described at www.uea.ac.uk/hr/joining-uea/staff-benefits
 
Closing date:  10 October 2020.
 
To apply for this vacancy, please follow the online instructions a https://www.neurotrans.org/

 

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  • PhD

01. Sepbember 2020
 

01 September 2020

Senior Computational Chemist Position, Cambridge, UK

skilled computational chemist at Sosei Heptares     
                                                                                 

Company Description

Sosei Heptares is an international biopharmaceutical group focused on the design and development of new medicines originating from its proprietary G Protein-Coupled Receptor (GPCR) targeted StaR® technology and Structure-Based Drug Discovery (SBDD) platform capabilities. The company is advancing a broad and deep pipeline of partnered and in-house drug candidates in multiple therapeutic areas including neurology, immunology, immuno-oncology, gastroenterology and rare/specialty diseases. Sosei Heptares is a world-leader in engineering of functional, stabilized GPCRs in their natural pharmacological conformations (agonist or antagonist), enabling the determination of 3D structures of GPCR-ligand complexes useful for SBDD. Sosei Heptares has approximately 145 employees based in the new R&D research facility at Granta Park in Cambridge, UK. The size of the company ensures a transparent linkage between all activities from early discovery through to clinical development.

Position

We are seeking a highly motivated and skilled Computational Chemist with experience in Computer-Aided Drug Design (CADD) and SBDD to join the Computational Chemistry team to assist Sosei Heptares in its drug discovery programs. This is an exceptional opportunity to participate in cutting-edge science using unique GPCR structural data whilst helping the growth and success of an industry-leading drug discovery company.

The computational chemist will work with our chemistry, pharmacology, biophysics and structural biology teams, and,

· Contribute to GPCR Structure-Based Drug Discovery projects by applying a broad set of computational chemistry and CADD approaches and developing structural protein-ligand interaction hypotheses to support and creatively contribute to data-driven molecular design and medicinal chemistry efforts.

· Develop, customise and apply computational medicinal chemistry and cheminformatics tools, workflows and models to extract, integrate, analyse and visualise complex chemical, structural, pharmacological and ADMET data within the context of structure-based drug discovery.

· Play an active role in new initiatives in GPCRome wide structural chemogenomics data driven virtual screening, GPCR optimised physics-based computer-aided drug design and generative molecular design approaches for GPCR SBDD.

Our preferred candidate will have the following profile:

· Ph.D. or equivalent experience in computational chemistry or a related discipline.

· Experience within a collaborative, multi-disciplinary, pharma/biotech environment with a track record of scientific achievements and contributions.

· Experience in supporting and executing structure-based drug design for lead generation and lead optimization with an experienced drug design team to develop novel compounds to enhance potency, selectivity and PK

· Skilled in computational chemistry/CADD approaches and strong familiarity with a wide range of current computational chemistry software suites for ligand-based and protein structure-based drug design, including bio/cheminformatics and structural chemogenomics data analysis, interpretation of crystallographic/cryoEM data, pharmacophore and QSAR modeling, protein homology modeling and molecular docking, and different virtual screening approaches.

· Demonstrable expertise in GPCR modeling and structure-based drug design is considered beneficial.

· Familiarity with Python scientific programming language and/or scientific workflow systems.

· Excellent interpersonal, oral and written communication skills: you will need to be able to communicate effectively with team members having diverse professional backgrounds.

· Strong team player with an inclusive, pro-active and positive can-do mindset that is willing to listen and learn from others.

For more information please see:
https://cezanneondemand.intervieweb.it/heptares/jobs/senior_computational_chemist_10511/en/

Please contact:

Chris De Graaf
PhD
Head of Computational Chemistry
+44 (0)1223 949210
+44 (0)7731 082157
Chris.DeGraaf@SoseiHeptares.com<mailto:Chris.DeGraaf@soseiheptares.com>

Steinmetz Building
Granta Park
Cambridge
CB21 6DG
United Kingdom

The information in this e-mail is confidential and may be legally privileged. It is intended for the exclusive attention of the addressee stated above and should not be copied or disclosed to any other. If you have received this transmission in error, please contact the sender immediately, make no use of its contents and delete this message from your system.
ontact and registered office address: Heptares Therapeutics Limited, Granta Park, Great Abington, Cambridge, CB21 6DG. Company No: 06267989.

This email and any attachments are intended solely for the use of the named recipients. If you are not the intended recipient you must not use, disclose, copy or distribute this email or any of its attachments and should notify the sender immediately and delete this email from your system. UK Research and Innovation (UKRI) has taken every reasonable precaution to minimise risk of this email or any attachments containing viruses or malware but the recipient should carry out its own virus and malware checks before opening the attachments. UKRI does not accept any liability for any losses or damages which the recipient may sustain due to presence of any viruses. Opinions, conclusions or other information in this message and attachments that are not related directly to UKRI business are solely those of the author and do not represent the views of UKRI.

 

 

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  • Professorship

25.08.2020
job for W1, tenure track W2 in Münster, Germany

 

 

 

26 August 2020

W1 Tenure Track W2 Theoratical Medicinal Chemistry

W1, tenure track W2

 

Junior professorship  W1 for theoretical medicinal chemistry with tenure track W2

For more details please see:
https://www.uni-muenster.de/Rektorat/Stellen/ausschreibungen/st_20202907_mb1.html

 

 

 

 

 

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  • PostDoc

24.08.2020

 

 

24 August 2020

Research Fellow in Virtual Human Cardiovascular Modelli

UCL and the Centre for Computational Science (CCS) have an opening for a postdoctoral research fellow to perform modelling and simulation of the cardiovascular system at the whole human scale.

principal Investigator: Professor P. V. Coveney

Start date: immediate
Salary (inclusive of London allowance): £35,965 to £43,470 per annum

The post-holder will work on scientific applications of HemeLB https://www.compbiomed.eu/services/software-hub/compbiomed-software-hemelb/ a flexible open source lattice-Boltzmann code for the simulation of human vasculature, and the Alya Red code https://www.compbiomed.eu/services/software-hub/compbiomed-software-alya/ for human heart modelling, at the scale of the entire human body. The coupled code, running on powerful supercomputers, will be used by the post-holder for research in physiology and medicine within the Centre of Excellence in Computational Biomedicine. In addition to the development and application of the code, including verification, validation and uncertainty quantification, the post-holder will facilitate uptake of these software within the wider computational biomedicine community.

The prospective candidate will join a very active multidisciplinary group at UCL producing research in wide-ranging applications, from biomedicine to advanced materials and quantum computing, and leading a number of large European and national projects giving exceptional opportunities for expanding the candidate’s network and experience.

A Ph.D. degree in physics, computer science, computer engineering, applied mathematics or chemistry, with experience in either the lattice-Boltzmann method or cardiac modelling, is an essential requirement. Experience in large-scale high-performance computing is also essential.

The post is funded by the European Commission and is available immediately, for a period of 24 months initially.

For more information, including the job description, visit our vacancies page http://ccs.chem.ucl.ac.uk/vacancies

Apostolos E. A. S. Evangelopoulos, PhD MInstP
University College London, Centre for Computational Science
20 Gordon Street, London, WC1H 0AJ

 

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  • PhD

07.07.2020
 

07 July 2020

PhD Student (M/F) for Ljubljana, Slovenia


Jožef Stefan InstituteLjubljana, Slovenia                                                                

https://ijs.si/ijsw

is the leading Slovenian scientific research institute, covering a broad spectrum of basic and applied research. The staff of more than 960 specializes in natural sciences, life sciences, and engineering. Soft condensed matter is among the main areas  pursued at the Institute, engaging several experimental laboratories and theoretical groups in close collaboration with the Department of Physics and the Institute of Biophysics at the University of Ljubljana.

The theoretical biophysics group is headed by Prof. PrimožZiherland currently includes four senior researchers  and several postdocs and PhD students. The group offers a competitive scientific environment with strong international collaborations.Full addressInstitut"Jožef Stefan”Jamova cesta391000 LjubljanaSloveniaThe theoretical biophysics group at the Department of Theoretical Physics, Jožef Stefan Institute, Ljubljana, Slovenia, is seeking aPhD student (M/F)to work on topics in the areas of theoretical and computational soft-matter physics and biophysics.

Starting date: October 1, 2020

Required qualifications:
MSc in physics, applied mathematics, computer science, or a related area (by September 14, 2020) strong interest in soft condensed matter and/or biophysics§good communication and organizational skills as well as the ability and interest to pursue challenging, interdisciplinary research§prior basic skills with computer simulations are welcome, but not required. Influency in written and spoken English

Job description:
The successful candidate will be supervised by Dr. Matej Kanduč (www-f1.ijs.si/~kanduc).
The research will focus on wetting phenomena, the formation and stability of nanobubbles, surfactants, lipid coatings, etc. The work will rely on molecular dynamics modeling approaches, numerical analysis, and analytical theories. The position envisions also collaboration with research groups abroad.

What we offer:
We provide a desktop computer, a travel allowance, as well as full access to HPC facilities. If successful, the candidate will receive a doctoral degree in Physics from the University of Ljubljana.

How to apply:
Please send the application including curriculum vitae, 1–2 letters of reference  to Matej Kanduč (matej.kanduc@ijs.si)at your earliest convenience, but not later than July 2020.

Jožef Stefan InstituteLjubljana, SloveniaThe Jožef Stefan Institute is the leading Slovenian scientific research institute, covering a broad spectrum of basic and applied research. The staff of more than 960 specializes in natural sciences, life sciences, and engineering. Soft condensed matter is among the main areas  pursued at the Institute, engaging several experimental laboratories and theoretical groups in close collaboration with the Department of Physics and the Institute of Biophysics at the University of Ljubljana. The theoretical biophysics group is headed by Prof. PrimožZiherland currently includes four senior researchers  and several postdocs and PhD students. The group offers a competitive scientific environment with strong international collaborations.

Full address
Institut"Jožef Stefan”
Jamova cesta 39
1000 LjubljanaSlovenia

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