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Manchester UK25 July 2019
Postdoctoral Research Associate
Enquiries about the vacancy, shortlisting and interviews:
Name: Professor Nigel Scrutton
Or: Prof. David Leys
Time-resolved structural biology of photoreceptor proteins
This project is based on recent research at Manchester on understanding the molecular mechanism of photoreceptor proteins, essential components of future industrial biotechnology applications. We have reported the complete reaction cycles of a number of bilin-containing photoreceptors using time-resolved spectroscopies. We showed that the photochemistry is coupled to long timescale structural change to enable downstream biological signalling. In addition, having previously investigated the photochemistry of coenzyme B12 alone and bound to B12 containing enzymes, we recently reported the photochemistry and mechanism of CarH (a member of a new superfamily of B12 photoreceptors). This provided a mechanistic basis for the emerging field of B12 photobiology and a new class of optogenetic tools for the control of gene expression. We are now well placed to map pathways of structural change in these and related, but more complex, multicentre photoreceptor proteins. Multicentre photoreceptors have recently been identified in the new family of B12 photoreceptor proteins but the basis of the photobiological response, is currently unknown and in particular how the photochemical events couple to protein structural change. This will require structural determination of the protein at each stage of their
photocycles, together with the timescales of these structural changes.
In this project we aim to develop a detailed dynamic structural understanding of a small number of target photoreceptors. We have teamed up with world-leading experts in the field of timeresolved structural biology at the IBS, who have pioneered the use of X-ray and neutron-based techniques to follow atomic motions in proteins on the ps-ms timescale. We will initially obtain high resolution (crystallographic) structural information of these proteins at Manchester and will take these forward for time-resolved structural studies together with the project partners in Grenoble, also making full use of the recently established XFEL hub at Diamond led by Dr Allen Orville.
Active crystals will provide the opportunity for unprecedented, high impact time-resolved structural studies using laser pulses to trigger the photoresponse and coupled pulses from synchrotron and XFEL sources to probe conformational changes along the reaction pathway. We will also use timeresolved
X-ray scattering (TRXS) measurements on the proteins in solution to follow large-scale structural changes (e.g. domain reorganisation) on μs–s timescales. The work builds on our established collaboration with the project partners in Grenoble in our studies of structural and dynamical changes in a light-activated enzymes and phytochrome photoreceptors.
Salary: Grade 6 £32,236 to £39,609 per annum according to experience
Hours: Full Time
Duration: Fixed Term from 1 October 2019 for 48 months
Location: Oxford Rd, Manchester
Reports To: Professor Nigel Scrutton, Professor David Leys and Dr Derren
Overall Purpose of the Job:
The appointee will drive the structural and time resolved structural biology analysis of selected photoreceptor proteins. This will involve overproduction, purification and (micro)crystallisation of the target proteins, data collection and structure determination, rational design and production of variant proteins and (post 2) time-resolved studies of structural change. A full time technician will support the more basic biochemical aspects of the project. Consequently we are seeking candidates with proven expertise in structural biology.
Key Responsibilities, Accountabilities or Duties:
• To take initiatives in the planning of research (design and perform experiments).
• To identify and develop suitable techniques, and apparatus, for the collection and analysis of data.
• To ensure the validity and reliability of data at all times.
• To maintain accurate and complete records of all findings.
• To actively read the scientific literature relating to (and around) the project.
• To write reports for submission to research sponsors and industrial collaborators.
• To prepare material for presentation in oral and poster formats, and present findings to colleagues, collaborators, and at conferences.
• To attend relevant meetings, including regular meetings with industrial collaborators.
• To draft publications and prepare them for submission to refereed journals.
• To contribute to writing bids for research grants.
• To undertake instruction of PhD students, supervise practical work and advise students on techniques as agreed.
• To attend relevant workshops and conferences as necessary.
• To work alongside the PI and other colleagues in a collegiate manner and build rapport within the team and the wider Faculty.
• To undertake any necessary training and/or development.
• To maintain safe workplace practice and procedures in accordance with the requirements of Health and Safety legislation.
• Any other duties commensurate with the grade of the post as directed by PI / supervisor.
Essential Knowledge, SkiBackground Informationlls and Experience:
• Hold (or expect to hold shortly) a PhD in one of the following areas: Structural biology, especially X-ray crystallography
• Experience/skills in conventional protein purification, basic spectroscopy and associated biochemical methods (electrophoresis; recombinant DNA work etc)
• Proven ability to use initiative to efficiently plan, optimise and progress project and communicate findings.
• Extensive IT skills.
• Excellent interpersonal and communication skills and ability to work with colleagues at all levels.
• Good written and spoken English.
• Theoretical and practical knowledge of time resolved approaches (post 1); mutagenesis and /or spectroscopy) post 2
The University of Manchester
The University of Manchester was the world’s first ‘industrial city’ and has since been a prodigious source of pioneers and innovators. Many major advances in the 20th century began in the University’s laboratories, such as the work by Rutherford leading to the splitting of the atom and the development of the world’s first stored programme computer by Williams and Kilburn. Today, research remains at the heart of The University of Manchester.
On October 1st 2004, The University of Manchester, created as a result of the merger of the Victoria University of Manchester and UMIST, became the largest in the UK, with an income of £600 million, more than 35,000 students and 11,000 staff. We have used the golden opportunity of its creation, and a £600 million capital programme to plan a revolutionary agenda. We have modernised management and administration, made long-term academic plans for all subjects, established key priorities for interdisciplinary research in areas of science and technology at the cutting edge of progress in industry and commerce, and set a target to more than double the volume of research activity performed in collaboration with external partners. By 2020, The University of Manchester aims to hold a world-class leading research profile and be among the top 25 universities worldwide. The University is pursuing this agenda in the context of the city of Manchester’s dramatic regeneration over the past 20 years. The aim is to make the world’s first industrial city a great post-industrial city. A vibrant culture of creative industries, entrepreneurs, and technology-based start-ups is served by iconic buildings and a re-modelled city centre – and now by a powerful, consolidated research university. Now and in the coming years we look forward to welcoming the very best staff, students and industrial partners from around the world.
Further information about the University and its faculties may be found on the University’s website (www.manchester.ac.uk). Manchester Institute of Biotechnology Biotechnology is a field of biology that involves the manipulation of living organisms and bioprocesses in engineering, technology, medicine and other fields for human benefit. Interdisciplinary in nature it draws on the pure biological sciences and in many instances is dependent upon knowledge and methods outside of biology at the engineering and physical sciences interface. The strong interdisciplinary focus and mode of operation in the MIB enables our scientists and engineers to drive state-of-the-art biotechnology research through establishing new types of collaboration. The MIB’s approach is pluralistic, integrative and non-exclusive functioning flexibly as a partner to researchers across a broad spectrum of disciplines which are fluid and constantly evolving. Using advanced quantitative methods to explore the relationship between the macro behaviour of biological systems and the properties of their nanoscale components we see this understanding as a basis for developing new biotechnologies that will find applications in areas
such as human health, the energy economy, food security, industrial transformations and the environment. A defining feature of our mission is the incorporation of rigorous, cutting-edge principles and technologies derived from the physical sciences, engineering, mathematics and computation into novel approaches to elucidating the molecular mechanisms that underpin living processes and systems. An extensive programme of technology development lies at the heart of our research programmes, driven by expertise from the quantitative sciences and engineering, allowing us to accelerate progress through the implementation of state-of-the-art enabling technologies.
The mission of the host lab is to understand the catalytic power of enzymes and synthetic
biology/metabolic engineering, and to exploit the use of enzymes in sustainable chemicals
biosynthesis and industrial biotechnology programmes.
Go to announcement
Johannes Kepler Universität Linz
25 July 2019
PhD Student Kepler Universität Linz
for 4 years:
The successful candidate will join the Membrane Transport Group (Head Peter Pohl) that is mainly interested in spontaneous and
facilitated transport of water, protons and other small molecules as well as in membrane protein translocation across the reconstituted
translocation channel. Preferentially we use electrophysiology, fluorescence correlation spectroscopy, light scattering (in stopped flow
mode) and electrochemical microscopy.
These will be your tasks:
You are (i) interested in the molecular mechanism of membrane channel function, (ii) willing to exploit photoswitchable elements to
govern channel function and (iii) to combine electrophysiological and optical techniques for channel investigation. In addition you will
tutor students in practical courses of biophysics.
You're offering these qualifications
You have a master degree in Physics, Biophysics, Biochemistry or a comparable qualification.
We're offering these benefits
Gross salary 29.500 €/year (after taxes and social insurances: ~ 21.800/year)
For details on the position please contact Univ.-Prof. Dr. Peter Pohl
(Tel.: +43-732-2468-7562)Go to announcement
2 Doktorratsstellen an der TU WIEN
Die Fakultät für Technische Chemie der TU Wien besetzt 2 freie Doktoratsstellen in ihrem Doktoratskolleg „bioactive“ in den Bereichen „Systems Biology“ und „Biophysics and Microscopy“.
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job offer at the University of Lugano USI / Switzerland01 July 2019
Post-doctoral Position in Switzerland
The research will focus on development and application of computational methods for biosimulations. Topic is GPCR receptors, from ligand binding to receptor activation and oligomerization. Our group is mostly involved in the development and application of the ligand binding free energy method called Funnel-Metadynamics (FM) (Limongelli et al. PNAS 2013, 110:6358-6363) and Coarse-Grained Metadynamics (CG-MetaD) simulations to investigate membrane proteins binding interaction (Lelimousin, Limongelli, Sansom JACS 2016, 138:10611-10622). Applicants are expected to have expertise in both atomistic and coarse-grained molecular dynamics simulations.
For further information:
Applicants are expected to have a solid base in physics and chemistry. The position is multi-year and salary above the European standard.
People interested should send an email email@example.com including the following documents:
• List of publications
• A brief statement of interest in our research
Go to announcement
Post-doctoral Research Worker
one year post-doctoral position in UK
We would like to invite applications for a Post-doctoral Research Worker position to work on a Computational Systems Biology project based on Protein-Protein Interaction Networks as primary interactome and using network analysis and graph theory tools to extract relevant biological information. Specifically, the project is aimed at identifying metabolic and signalling pathways disrupted in C9orf72-linked Amyotrophic Lateral Sclerosis/Frontotemporal Dementia. The project is funded by the Motor Neurone Disease Association under the supervision of Dr Jean-Marc Gallo and Professor Franca Fraternali. The successful candidate will have completed a PhD in a relevant subject, such as Bioinformatics, Computational Biology, Applied Mathematics, Statistical Physics and related fields. Experience in network analysis is essential while a background in a biology-related subject is desirable but not essential. The project is entirely computer-based and parts of it could be conducted remotely. The successful applicant will have the ability to work independently and have good team working skills so as to interact productively as a member of the research group.
The salary will be paid at Grade 6, £33,518 per annum, plus £2,923 per annum London Allowance.
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Postdoctoral and Phd Position in Membrane Biophysics
We are seeking highly committed candidates for a postdoctoral position (2.5 yrs) and a PhD position (4 yrs) in the framework of the project “Effect of Lipid Asymmetry on the Activity of Outer Membrane Phospholipase A (OmpLA)” granted by the Austrian Science Fund (FWF).
The central aim of the project is to (i) reconstitute OmpLA in different asymmetric lipid vesicles and (ii) characterize of its enzymatic activity using small-angle scattering techniques and physicochemical assays. The work will be performed in close collaboration with international key researchers in the field, including extended visits for laboratory training.
We offer employment at the University of Graz, in a top-notch scientific environment at the interface of biophysics, physical chemistry and structural biology. Your application includes: letter of intent, CV, certificates, and contact information of previous supervisors. The deadlines for applications are August 16, 2019 for the PhD and October 4, 2019 for the PostDoc position, respectively (send PDFs to firstname.lastname@example.org).
Information and profile requirements specific to PostDocs:
• PhD in biophysics, physical chemistry, or soft matter physics
• Distinct experience in elastic small-angle neutron and X-ray scattering experiments (including contrast variation) and data modelling (ideally on lipid membranes and proteoliposomes)
• Gross salary: EUR 3,803.90.- / month, 14 times a year
• Expected starting date: January/February 2020
Information and profile requirements specific to PhDs:
• Master’s degree in biophysics, physical chemistry, chemistry, physics, chemical engineering, or molecular biology
• Experience in laboratory work (biophysics, chemistry, biological samples/assays, cells), or eagerness to learn rapidly.
• Gross salary: EUR 2,162.40.-/ month, 14 times a year
• Expected starting date: October 2020
General profile for both positions:
• Distinct skills in:
o analytical thinking
o organization of complex experiments
o communication (oral and written)
o teamwork and working/learning in a highly interdisciplinary research area
• Scientific commitment and creativity
• Willingness to travel for experiments to synchrotron and neutron sources
For additional information, send an email to email@example.com or see https://homepage.unigraz.at/de/georgpabst/.Go to announcement
Haifa, Israel07 February 2019
Single molecule studies on chromatin and transcription fa
A number of PhD student and postdoc positions are available in the single-molecule biophysics group. We use high-resolution optical tweezers to study the interplay between chromatin structure and dynamics, transcription factors and polymerases, and their role in the regulation of gene expression.
For more information please visit: https://kaplan.net.technion.ac.il/
Students with a background in biology or physics are welcome to apply.Go to announcement
Oberösterreich, Linz14 January 2019
Cell Scaffold Development for Stem Cell Differentiation
The position is part of the FWF funded project “3D Lithographical Scaffolds for Stem Cell Differentiation". This is a collaborative project of the two groups of Prof. Klar at the Johannes Kepler University (JKU), Linz (3D lithography) and of Prof. Jacak at the University of Applied Sciences, Linz (fluorescence microscopy, cell-cell interactions and stem cell differentiation). Within this project, you will develop 3D, extracellular matrix-mimicking cell scaffolds and study the influence on stem cell differentiation and cell-cell interactions. You will develop complex scaffolds, written with two photon lithography and/or STED lithography at JKU, allowing for feature sizes ranging from micro- down to nanometers). Such scaffolds shall be seeded with mesenchymal stem cells and the cell-cell as well as cell-scaffold interactions will be investigated in-vitro at the nanoscopic level. Your work includes training on the following techniques: MPL-lithography, STED-lithography, fluorescence microscopy and localization microscopy (dSTORM). The position shall be filled as soon as possible. The candidate will be initially hired for one year, but funding for a total of three years is available if the project develops well. The candidate may use the results for a PhD thesis.
Formal requirements: MSc degree (or equivalent) in physics, biochemistry or polymer chemistry. Experimental experience in optics, biophysics, lithography or fluorescence microscopy would be of advantage. The ability to work independently in the lab, creativity, and the motivation to work in an interdisciplinary team are expected.
- Pursuit of an interesting, current and medically/clinically relevant topic
- Work in a cooperative, interdisciplinary atmosphere in 2 highly equipped labs
- Proper supervision
- Possibility to visit national and international conferences/workshops
Please provide your application with:
- 1-page cover letter stating your motivation and background for applying for the position
- Diploma and transcripts of records (BSc and MSc)
- Full contact details (Name, address, telephone & email) of 1-3 professional referees
We especially encourage women to apply.
The university welcomes applications from qualified applicants who have physical disabilities. These applications will be given special consideration.
Univ.-Prof. Dr. Thomas A. Klar, Institute of Applied Physics, Johannes Kepler University, Linz, Austria
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