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  • Assistant Professor in Biophysics, Japan
24 June 2019

Research Scientist

We are now recruiting a research scientist as an Assistant Professor (non-tenured) at WPI Nano Life Science Institute (WPI-NanoLSI), Kanazawa University.
The candidate will develop innovative projects applying high-speed nanoprobe techniques, including atomic force microscopy (HS-AFM) and scanning ion conductance microscopy (HS-SICM), for the observation of dynamic intracellular protein processes.


Specific projects:

The Biophysics Lab (http://biophys.w3.kanazawa-u.ac.jp/index.htm) has been developing HS-AFM and HS-SICM imaging techniques to obtain direct mechanistic insights into the dynamic action of protein molecules that cannot be achieved in other ways. HS-AFM is also emerging as a powerful tool to image dynamic processes occurring at the plasma membrane of living cells. However, investigating intracellular protein dynamics requires partially or fully removing the cell membrane before a nanoprobe can be inserted into the cell for high-resolution imaging. Furthermore, cellular structures are often softer compared to purified protein samples on solid supports, and therefore require especially soft imaging techniques, such as SICM. In this project, different detergent-based and gentle mechanical cellular de-roofing methods will be combined to expose intracellular organelles for high-speed scanning, while retaining physiological conditions and keeping the exposed intracellular protein complexes functional. All de-roofing steps will be closely monitored using light microscopy, as well as a novel label-free 3D holographic microscopy technique, to ensure minimal cell damage. Your contribution will include some or all of the following: 1. Preparation of functional protein complexes and intracellular organelles from unroofed mammalian cells. 2. Imaging of the exposed cellular organelles by HS-AFM and HS-SICM. 3. Inspection and improvement of developed techniques. 4. Development of SICM probes for high resolution.
Host Institution: In 2017 NanoLSI was adopted by JSPS as a World Premier International Research Center Initiative (WPI). At NanoLSI we combine the world’s most advanced technologies in bio-scanning probe microscopy to image, analyze, and manipulate the nanodynamics of proteins, metabolites, and nucleic acids both on the surface of and inside cells. In this way, we aim to achieve a fundamental understanding of nano-level mechanisms underlying basic cellular functions, such as proliferation, differentiation, stemness, signal transduction, genome dynamics, and cancer-specific abnormalities. The aim of the entire project can be found at nanolsi.kanazawa-u.ac.jp/en/

Requirements:
1. PhD in either biophysics, molecular biology, biochemistry, cell biology, engineering, or a related discipline.
2. Experience working with AFM or SICM is advantageous but not obligatory.
3. Self-motivated and able to work in a multidisciplinary team.
4. Good English communication skills.


Application deadline: July 15th, 2019;
Start Date: September 1st, 2019, or as soon as possible thereafter.


Contract: Non-tenured full-time job. Three-year fixed-term contract. There is a possibility for contract renewal upon review of achievements. The annual salary includes a basic pay of 4,200,000 yen and a special allowance of ~1,320,000 yen in accordance with the rules of Kanazawa University. Salary will be fluctuated by performance and evaluation after adoption. We will provide a start-up research fund of 1,000,000 yen in the first year.


How to apply:
Send the following documents to Clemens Franz (clemens.franz@staff.kanazawa-u.ac.jp) via e-mail, with the headline “NanoLSI Assistant Professor, Franz”.
1. CV with a recent photograph
2. List of publications, presentations and other relevant activities,
3. PDF files of published papers (up to three),
4. List of research support (time period, name of grant, title of education/research, and amount of money),
5. Motivation letter,
6. Descriptions of your skills, previous studies (and teaching experiences: not mandatory) on two pages,
7. Reference letters from two scientists including a former academic supervisor.

 

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  • PostDoc
  • Postdoctoral Fellow Position in Liverpool

in Liverpool / UK from October 2019 for four years

18 June 2019

Postdoctoral Fellow Position in Liverpool

Applications are invited for a postdoctoral fellow position in the laboratory of Dan Rigden at the University of Liverpool. The position involves translating protein bioinformatics methods to applications in structural biology.

As part of the CCP4 software consortium, we are looking for a PDRA to develop methods that exploit evolutionary covariance-derived information for the benefit of structural biologists. The work, some in collaboration with CCP4 partners, will use covariance information to help parse domains, to guide and validate map interpretation and to develop novel methods to address the phase problem in X-ray crystallography.

You should have a PhD degree (or equivalent experience) in Informatics, Bioinformatics or in a Biological Science with experience of bioinformatics. You should have excellent programming skills and experience of research in computational or structural biology.

 

 

 

 

 

 

 

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  • PostDoc

Postion in Western Australia, University of Perth

18 June 2019

F/T Postdoctoral Position in Western Australia, Perth

A full time postdoctoral position is available in the Cardiovascular Electrophysiology Laboratory at The University
of Western Australia in Pert
h. We are seeking an experienced electrophysiologist to work on characterising L type
calcium channel function in murine CRISPR mutant models. Experience in animal physiology and biochemistry is
also highly desirable.

The University of Western Australia (UWA) is a research intensive university and one of the internationally
recognised Australian Group of Eight that also comprises the University of Queensland, The University of Sydney,
The University of New South Wales, Australian National University, The University of Melbourne, Monash
University and The University of Adelaide. These universities are regarded as the nation’s leading research and
comprehensive institutions. Situated on the Swan River in Crawley, UWA is one of Australia’s most picturesque
campuses. Perth is Australia’s fourth largest city and capital of the thriving State of Western Australia. Voted as one
of the world’s most liveable cities, the inhabitants of Perth enjoy a climate and lifestyle that is envied by many.
The Cardiovascular Electrophysiology Laboratory is situated on the Crawley campus in the School of Human
Sciences.

The laboratory is led by Professor Livia Hool who is affiliated with Victor Chang Cardiac Research
Institute as Faculty at Large. Her research focuses on understanding the role of the cardiac L type calcium channel
in health and disease. Her team is characterising alterations in calcium channel function in ischemic heart disease
and familial cardiomyopathies. The goal of her research team is the prevention and treatment of cardiomyopathy.
The multidisciplinary research with collaborators from Harvard University, Washington University, University of
California Los Angeles, Sydney University, The Harry Perkins Institute for Medical Research, Murdoch University
and The University of Western Australia involves the use of innovative treatment approaches such as antisense
oligomer exon skipping chemistry, nanoparticle technology and CRISPR technology to manipulate gene function
or further enhance delivery and uptake of therapeutic peptides and oligomers into the heart.

Job Requirements:

  • Experience in patch
  • clamp measurement of ion channels, single channel and/or macroscopic currents.
  • Experience in animal physiology (measurement of cardiac contractile function by left ventricular catheterisation,
  • echocardiography), and biochemistry (immunoblot technique, FURA 2 fluorescent detection of calcium) is highly desirable.

 

 

 

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  • PostDoc
13 June 2019

Postdoctoral Position in Melbourne

Prof Irene Yarovsky at RMIT, Melbourne, has a postdoctoral position available in her group.  

The project is focused on Materials Modelling & Simulation is part of the NHMRC Centre of Research Excellence for Electromagnetic Bioeffects.

Full-time, Fixed-term 3-year contract with the possibility of extension
Excellent professional development with combination of research, developing new techniques and mentorship in the area of biomolecular simulations
Research collaboration with researchers from 5 Australian Universities and internationally
Day-to-day reporting to Professor Irene Yarovsky, Chief Investigator & RMIT Node Leader of NHMRC Center of Research   Excellence for Electromagnetic Bioeffects Research
Open to Academic Level A or Level B, with competitive salary packaging + 17% superannuation

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  • PostDoc
11 June 2019

Post-doctoral Research Worker

one year post-doctoral position in UK

We would like to invite applications for a Post-doctoral Research Worker position to work on a Computational Systems Biology project based on Protein-Protein Interaction Networks as primary interactome and using network analysis and graph theory tools to extract relevant biological information. Specifically, the project is aimed at identifying metabolic and signalling pathways disrupted in C9orf72-linked Amyotrophic Lateral Sclerosis/Frontotemporal Dementia. The project is funded by the Motor Neurone Disease Association under the supervision of Dr Jean-Marc Gallo and Professor Franca Fraternali. The successful candidate will have completed a PhD in a relevant subject, such as Bioinformatics, Computational Biology, Applied Mathematics, Statistical Physics and related fields. Experience in network analysis is essential while a background in a biology-related subject is desirable but not essential. The project is entirely computer-based and parts of it could be conducted remotely. The successful applicant will have the ability to work independently and have good team working skills so as to interact productively as a member of the research group.

The salary will be paid at Grade 6, £33,518 per annum, plus £2,923 per annum London Allowance.
http://fraternalilab.kcl.ac.uk/wordpress/

 

 

 

 

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  • PhD
  • PostDoc
23 May 2019

Postdoctoral and Phd Position in Membrane Biophysics

We are seeking highly committed candidates for a postdoctoral position (2.5 yrs) and a PhD position (4 yrs) in the framework of the project “Effect of Lipid Asymmetry on the Activity of Outer Membrane Phospholipase A (OmpLA)” granted by the Austrian Science Fund (FWF).
The central aim of the project is to (i) reconstitute OmpLA in different asymmetric lipid vesicles and (ii) characterize of its enzymatic activity using small-angle scattering techniques and physicochemical assays. The work will be performed in close collaboration with international key researchers in the field, including extended visits for laboratory training.


We offer employment at the University of Graz, in a top-notch scientific environment at the interface of biophysics, physical chemistry and structural biology. Your application includes: letter of intent, CV, certificates, and contact information of previous supervisors. The deadlines for applications are August 16, 2019 for the PhD and October 4, 2019 for the PostDoc position, respectively (send PDFs to georg.pabst@uni-graz.at).


Information and profile requirements specific to PostDocs:
• PhD in biophysics, physical chemistry, or soft matter physics
• Distinct experience in elastic small-angle neutron and X-ray scattering experiments (including contrast variation) and data modelling (ideally on lipid membranes and proteoliposomes)
• Gross salary: EUR 3,803.90.- / month, 14 times a year
• Expected starting date: January/February 2020
Information and profile requirements specific to PhDs:
• Master’s degree in biophysics, physical chemistry, chemistry, physics, chemical engineering, or molecular biology
• Experience in laboratory work (biophysics, chemistry, biological samples/assays, cells), or eagerness to learn rapidly.
• Gross salary: EUR 2,162.40.-/ month, 14 times a year
• Expected starting date: October 2020
General profile for both positions:
• Distinct skills in:
o analytical thinking
o organization of complex experiments
o communication (oral and written)
o teamwork and working/learning in a highly interdisciplinary research area
• Scientific commitment and creativity
• Willingness to travel for experiments to synchrotron and neutron sources

For additional information, send an email to georg.pabst@uni-graz.at or see https://homepage.unigraz.at/de/georgpabst/.

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  • PhD
  • PostDoc

Haifa, Israel

07 February 2019

Single molecule studies on chromatin and transcription fa

A number of PhD student and postdoc positions are available in the single-molecule biophysics group. We use high-resolution optical tweezers to study the interplay between chromatin structure and dynamics, transcription factors and polymerases, and their role in the regulation of gene expression.

For more information please visit: https://kaplan.net.technion.ac.il/

Students with a background in biology or physics are welcome to apply.

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  • PhD

Deutschland, Halle

06 February 2019

Intrinsically Disordered Proteins - Molecular Principles,

Funding for new Research Training Group RTG 2467 „Intrinsically Disordered Proteins - Molecular Principles, Cellular Functions, and Diseases“ granted by the DFG,

11 PhD Positions
Start: June 1, 2019

RTG Website: www.rtg2467.uni-halle.de
Mail: rtg2467@pharmazie.uni-halle.de

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  • PhD

Oberösterreich, Linz

14 January 2019

Cell Scaffold Development for Stem Cell Differentiation

The position is part of the FWF funded project “3D Lithographical Scaffolds for Stem Cell Differentiation". This is a collaborative project of the two groups of Prof. Klar at the Johannes Kepler University (JKU), Linz (3D lithography) and of Prof. Jacak at the University of Applied Sciences, Linz (fluorescence microscopy, cell-cell interactions and stem cell differentiation). Within this project, you will develop 3D, extracellular matrix-mimicking cell scaffolds and study the influence on stem cell differentiation and cell-cell interactions. You will develop complex scaffolds, written with two photon lithography and/or STED lithography at JKU, allowing for feature sizes ranging from micro- down to nanometers). Such scaffolds shall be seeded with mesenchymal stem cells and the cell-cell as well as cell-scaffold interactions will be investigated in-vitro at the nanoscopic level. Your work includes training on the following techniques: MPL-lithography, STED-lithography, fluorescence microscopy and localization microscopy (dSTORM). The position shall be filled as soon as possible. The candidate will be initially hired for one year, but funding for a total of three years is available if the project develops well. The candidate may use the results for a PhD thesis.
Formal requirements: MSc degree (or equivalent) in physics, biochemistry or polymer chemistry. Experimental experience in optics, biophysics, lithography or fluorescence microscopy would be of advantage. The ability to work independently in the lab, creativity, and the motivation to work in an interdisciplinary team are expected. 

Benefits:

  • Pursuit of an interesting, current and medically/clinically relevant topic
  • Work in a cooperative, interdisciplinary atmosphere in 2 highly equipped labs
  • Proper supervision
  • Possibility to visit national and international conferences/workshops

Please provide your application with:

  • 1-page cover letter stating your motivation and background for applying for the position
  • CV
  • Diploma and transcripts of records (BSc and MSc)
  • Full contact details (Name, address, telephone & email) of 1-3 professional referees

We especially encourage women to apply. 
The university welcomes applications from qualified applicants who have physical disabilities. These applications will be given special consideration.

Research group:
Univ.-Prof. Dr. Thomas A. Klar, Institute of Applied Physics, Johannes Kepler University, Linz, Austria

Contact persons: 
Thomas A. Klar: thomas.klar@jku.at 
Jaroslaw Jacak: jaroslaw.jacak@fh-linz.at

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