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  • PostDoc

Tel Aviv University
16.05.2020

16 May 2020

Post Doctoral Position Tel Aviv University

Post-Doctoral Position: Unraveling Membrane Fusion Mechanisms Using Mechanical Single-Molecule Methods At the newly-founded group of Dr. Raya Sorkin, Department of Physical Chemistry, School of Chemistry, Tel Aviv University, Israel https://sorkinraya.wixsite.com/sorkinlab.

Start Date: Flexible Term of appointment: 1 year initial appointment, renewal upon mutual agreement for additional 1/2 years. Salary: Starting from 10,000 NIS net per month. Project Overview: Fertilization is a multistep and complex process culminating in gamete fusion, leading to zygote formation which then develops to form a new individual. Even though the fusion of egg and sperm membranes is a key event in this process, there is still very little known about its mechanism. The aim of this project is to reveal the role and action mechanisms of key proteins in the fusion process, using a combination of microscopy and mechanical single-molecule techniques (including optical tweezers and AFM). The approach includes developing controlled model systems, such as micro-beads coated with membranes of defined composition with incorporated proteins of interest, to quantitatively study protein-protein and protein-membrane interactions. Your profile: For this interdisciplinary project, we look for a trained experimentalist with a strong record of research in biophysics or soft matter, preferably with prior experience with membrane model systems (e.g., GUVs, GPMVs) or force-spectroscopy. A Ph.D. in biophysics, physics, chemistry, biochemistry, molecular biology or a related field is required. Additional qualifications: fluent in English (spoken and written), self-motivated, and able to thrive in a collaborative and multidisciplinary environment. Our lab is equipped with state of the art instrumentation for single-molecule mechanical studies. We are affiliated with the Center for the Physics and Chemistry of Living Systems at Tel Aviv University that provides a most stimulating environment for biophysical research by bringing together groups from various disciplines that study biophysical problems by a wide range of approaches. The campus is located in the north of Tel Aviv, which is a fun and vibrant city with international atmosphere. To apply: Interested candidates should apply directly to

Dr. Sorkin
rsorkin@tauex.tau.ac.il

and provide the following: • Curriculum vitae • Cover letter describing your prior experience and motivation to join our lab • Names and contact information for at least two references

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  • PhD

Marie Sklodowska Curie
16.05.2020

16 May 2020

15 PdD Positions within the MSCA-ITN-ETN Neuro Trans

NEUROtransmitter TRANSporters: From single molecules to human
pathologies
The European Training Network (ETN) NeuroTrans (NEUROtransmitter TRANSporters: From
single molecules to human pathologies) announces 15 PhD candidate positions for Early-Stage
Researchers (ESRs) with the option of being awarded a doctoral degree. NeuroTrans is an
Innovative Training Networks (ITN) from the Marie Skłodowska-Curie (MSCA) Actions
Programme

https://ec.europa.eu/programmes/horizon2020/en/h2020-section/marie-Sk%C5%82odowska-curie-actions

funded by the European Commission under the framework of Horizon 2020. The
NeuroTrans ETN (Grant number 860954) will establish an international training programme by
forming a highly interdisciplinary team of world-leading European researchers from 9 universities
and 5 industrial partners. NeuroTrans makes ample use of existing cutting-edge methods to reach
this goal, but also develops enabling techniques in biophysics, molecular and structural biology.
The vision of the NeuroTrans project is:
 to reach a comprehensive understanding of neurotransmitter:sodium symporter (NSS)
function ranging from the molecular level to human pathologies,
 to investigate how psychoactive substances target these transporters,
 to elucidate how disruption of transporter function contributes to neuropsychiatric disease
pathobiology.
To accomplish our vision, NeuroTrans will establish an interdisciplinary training school that
includes most important subdisciplines in quantitative biology, including molecular modelling,
computer simulations, biophysics, biochemistry, neurobiology, human pathology, molecular and
structural biology, but also engineering and programming. Through the training offered by
NeuroTrans, PhD candidates will develop a cutting edge set of skills ranging from computer
simulations to membrane protein structural biology, dynamics and thermodynamics to human
diseases, pathologies and instrument development. By integration of the industrial sector in the
training, NeuroTrans will offer training in entrepreneurship, product development and
commercialisation to prepare the NeuroTrans students for acquiring leading positions in academia
and industry.
Details on the NeuroTrans programme and the recruitment can be found on the NeuroTrans
homepage (www.neurotrans.org). The positions are available at 9 universities and 3 companies in 8
different European countries. Employment is according to the regulations by the hosting university
or company and the rules of the Marie Skłodowska-Curie Actions. All Marie Skłodowska-Curie
Actions funded ESR position positions are limited to a duration of 36 months, but can be extended
according to national regulations. The PhD candidate will enroll in a university PhD programme.
Applicants should consult the homepage of NeuroTrans (www.neurotrans.org)
for complete information.
Applications need to be directed to the NeuroTrans consortium (office@neurotrans.org).
The 15 projects of NeuroTrans are:
Project 1) Molecular insights into the role of lipids and regulatory proteins on sodium
coupling and inhibition of the GABA transporters BGT1 and GAT1.
Hosting institution and working location: University of Regensburg, Germany
Principal investigator: Christine Ziegler
Project 2) NMR based structural and dynamic investigation of the transport cycle of NSS
transporters
Hosting institution and working location: NOVA University of Lisbon, Portugal
Principal investigator: Eurico Cabrita
Project 3) Purification, functional characterization and reconstitution of DAT and LeuT.
Hosting institution and working location: University of Copenhagen, Denmark
Principal investigator: Claus Løland
Project 4) Development of a comprehensive model of GABA transporter function
Hosting institution and working location: Medical University of Vienna, Austria
Principal investigator: Thomas Stockner
Project 5) Electrophysiological characterization of NSS transporters and formulation of an
overall kinetic model
Hosting institution and working location: Nanion, Munich, Germany
Principal investigator: Andre Bazzone
Project 6) Electrophysiological approaches to study, ion coupling and transport by NSS
transporters
Hosting institution and working location: University of Insubria, Italy
Principal investigator: Elena Bossi
Project 7) Kinetics of substrate transport for deduction of mechanistic models of the transport
cycle
Hosting institution and working location: University of Groningen, The Netherlands
Principal investigator: Dirk Slotboom
Project 8) Development of a cloud-based data pipeline to enable data-driven analysis for the
determination of transporter-ligand binding thermodynamics
Hosting institution and working location: Nanotemper, Munich, Germany
Principal investigator: Julia Baldauf
Project 9) Integrative modelling of ligand binding, transporter stability and the transport
cycle
Hosting institution and working location: Medical University of Vienna, Austria
Principal investigator: Thomas Stockner
Project 10) Time resolved structural studies of membrane transporters
Hosting institution and working location: University of Hamburg, Germany
Principal investigator: Arwen Pearson
Project 11) Single-molecule studies of secondary-active transporters and their environmental
dependence.
Hosting institution and working location: Ludwig-Maximilans University Munich,
Germany
Principal investigator: Thorben Cordes
Project 12) Resolving coarse-grained dynamic distance constraints of the transport cycle of
NSS transporters using EPR spectroscopy
Hosting institution and working location: University of East Anglia, UK
Principal investigator: Fraser MacMillan
Project 13) Characterization of the molecular mode of action of novel psychoactive substances
Hosting institution and working location: Medical University of Vienna, Austria
Principal investigator: Harald Sitte
Project 14) Development of a microfluidic cell perfusion station for controlled compound
delivery and real time fluorescence monitoring
Hosting institution and working location: Elvesys, France
Principal investigator: Christa Ivanova
Project 15) Assessing the molecular determinants of novel disease causing mutations in DAT
Hosting institution and working location: University of Copenhagen, Denmark
Principal investigator: Ulrik Gether
Application
Applicants should email the completed application form and all other requested documents and
information to the NeuroTrans office: office@neurotrans.org. The language for applying to
NeuroTrans is English. At the time of application, applicants do not need to have finished their
Master's study (or equivalent) that allows for enrolling in a PhD programme, but it must be
completed at the time of recruitment to the hosting institution. Applicants may apply for a
maximum of three positions and must indicate their preference in the application form.
Applications (provided as a single PDF file) should include the following documents:
 Curriculum Vitae (Europass format preferred)
 Contact information of two senior referees. Note that you must contact your referees and
make sure that they independently send a reference letter to office@neurotrans.org. The
reference letters should be on institutional headed paper and come from the referee's
institutional rather than personal email address. We will not contact your referees; it is your
responsibility to ensure that references reach us by the application deadline.
 Completed Application Form of the European Training Network (ETN) NeuroTrans can be
downloaded from the NeuroTrans homepage (www.neurotrans.org).
 Certificates of university degrees and intermediate certificates. If a Master's degree (or
equivalent) has not been obtained, this must be stated and the estimated date of completion
must be provided. The degree allowing for enrollment in a PhD programme needs to be
completed at the time of commencing the employment contract.
 Academic record: University transcripts, including photocopies of transcripts of marks
(academic record).
 University transcripts documenting your career must be sent in one of the NeuroTrans
languages, preferably English (Danish, Dutch, English, German, French, Italian, and
Portuguese are also accepted).
 Additional documents (if available) supporting your applications that can include language
certificates, additional education certificates or training certificates. The complete
application requirements are described on the homepage of NeuroTrans
(www.neurotrans.org).
After the deadline, applications will be evaluated by the supervisory board. Interviews with
shortlisted candidates will be conducted through videoconferencing. Candidates will be selected by
an evaluation panel and the supervisory board of NeuroTrans. Selected PhD candidates will be hired
by the hosting institution and enroll in a university PhD programme. All Marie Skłodowska-Curie
Actions funded ESR positions are limited to a duration of 36 months, but can be extended according
to national regulations. See the NeuroTrans homepage for further details.
Eligibility Criteria
The PhD candidates must fulfill the following conditions to be eligible as PhD candidate for
NeuroTrans:
 Excellent oral and written English language skills
 At the date of commencing their employment, be in the first four years (full-time equivalent
research experience) of their research careers, including any period of research training. The
time is measured from the date when the PhD candidate obtained the first degree entitling
him/her to embark on a doctorate (either in the country in which the degree was obtained or
in the country in which the PhD candidate is recruited, even if a doctorate was never started
or envisaged).
 At the time of recruitment be in possession of a university degree that allows for enrolling in
a PhD programme, but have not completed a PhD. Being already enrolled in a PhD
programme (unfinished) does not constitute an exclusion criterium. Date of commencing
their employment means the first day of the employment of the PhD candidate (i.e. the
starting date indicated in the employment contract or equivalent direct contract).
 PhD candidates must not have resided or carried out their main activity (work, studies, etc.)
in the country of the recruiting university of company for more than 12 months in the 3
years immediately before the recruitment date. This time is measured from the date of
signing the employment contract. Compulsory national service, short stays such as holidays,
and time spent as part of a procedure for obtaining refugee status under the Geneva
Convention are not taken into account. Compulsory national service, short stays such as
holidays, and time spent as part of a procedure for obtaining refugee status under the Geneva
Convention are not taken into account.
 Have a Master' s degree (or an equivalent diploma allowing to pursue a PhD) in the fields as
requested for each NeuroTrans projects. See further details at the homepage of NeuroTrans
(www.neurotrans.org)
 Additional recruitment criteria for each project/PhD position can be found on the
NeuroTrans homepage (www.neurotrans.org).
 The PhD candidate can be of any nationality.
See further details in the Guide for Applicants Marie Skłodowska-Curie Actions Innovative
Training Networks.
Remuneration
The successful candidates will receive a 36-month, full-time employment contract as per Marie
Skłodowska-Curie Actions (MSCA) regulations for Early Stage Researchers (ESRs). The gross
salary is comprised of the following three standard EU allowances: Living allowance: €3270;
Monthly allowance: €600; Family allowance: €500. The listed gross living allowance are adjusted
through the multiplication with the country correction coefficient (Austria=1.067; Denmark=1.350;
France=1.157; Germany=0.970; Italy=1.044; Portugal=0.842; The Netherlands=1.079; United
Kingdom=1.398) according to Marie Skłodowska-Curie Actions regulations.
Living Allowance
The PhD candidates will be appointed according to the applicable employment contracts of the
hosting institution / company. The monthly gross living allowance is subject to deductions of
employer' s and employee' s contributions to National Insurance, income tax, etc. . This adjustment
reflects the average difference in living cost between European countries.
Monthly Allowance
All eligible PhD candidates recruited within NeuroTrans are entitled to receive this gross allowance.
It contributes to the mobility related expenses.
Family Allowance
A gross family allowance will be paid should the researcher have family, regardless of whether the
family will move with the researcher or not. In this context, family is defined as persons linked to
the researcher by (i) marriage, or (ii) a relationship with equivalent status to a marriage recognised
by the national or relevant regional legislation of the country where this relationship was
formalised; or (iii) dependent children who are actually being maintained by the researcher. The
family status of a researcher will be determined at the date of their (first) recruitment in the action
and will not evolve during the action lifetime.

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  • PhD

Trieste, Italy
07.05.2020
 

07 May 2020

3-years PhD Scholarship in Trieste/ Italy

There is an opening for a 3-years PhD Scholarship with the Graduate Program in Nanotechnology, at the University of Trieste, Italy: http://web.units.it/dottorato/nanotecnologie/en

Starting date: November 2020
Application deadline: June 10th 2020
Admission examination by July 10 2020 (for exact dates please follow the call on the website)

PhD Project title:
Multimodal Phase Imaging and Optical Manipulation for Biomarker Characterization in Biomedicine

Description
Multimodal Phase Imaging (MPI) includes holography and speckle real-time imaging to assess cellular and subcellular biomechanical information in living cells: cell volume, dry mass, nucleus volume, membrane dynamics. Quantified, this information represents the base for free-label biomarker definition and characterization. Optical Manipulation (OM) on the other hand, uses laser light to trap and manipulate micro and nanoparticles in fluid. Combining imaging and manipulation modalities into a multimodal platform enables fast diagnosis of dry and wet biopsies in Biomedicine. The aim of this PhD project is to combine MPI and OM into a common device and develop a fast technique for liquid biopsy with high sensitivity and specificity. The project will be developed in the Nano-Biomechanics Lab at the Italian National Research Council CNR-IOM Trieste .

See our homepage: https://www.iom.cnr.it/

Optimization of existent instrumentation and experimental techniques and development of new methods are planned in interaction with local biomedical engineering industry.

We seek an enthusiastic and motivated candidate with a master’s degree in applied physics, engineering or biotechnology. A background in numerical simulation and microscopy would be an asset. The successful candidate will collaborate with other researchers in the group, as well as with collaborative industrial partners and scientific community. Visits to other collaborative organizations and presentation of scientific work at conferences will be encouraged.


Contact: Dr. Dan Cojoc,
Email: mailto:cojoc@iom.cnr.it

 

 

 

 

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  • PhD
  • PostDoc

23 March 2020
 

23 March 2020

PhD AND Post Doc at the Max Planck Institute, Göttingen

The Max Planck Institute for Biophysical Chemistry is one of the largest institutes of the Max Planck Society for the Advancement of Science and conducts basic research to advance knowledge and benefit society. Innovative projects and interdisciplinary cooperation characterize research within the Max Planck Society.

The research group of 
https://www.mpibpc.mpg.de/17239845/06-20
https://www.mpibpc.mpg.de/degroot

(Prof. Dr. Bert de Groot) invites applications for a position as

PhD Student or Postdoc (f/m/d)
(Code number 06-20)

for the projects

Gating Mechanisms and Regulation of Ion Permeation in Potassium Channels –

– Alchemical free energy calculations in protein and ligand design –

The successful candidate for either position has a keen interest and strong skills in computational molecular biophysics and skills in structural biology, physical chemistry, statistical mechanics and biocomputing, and a strong interest in interdisciplinary collaborative research.

PhD candidates hold (or expect to complete soon) a Masters or equivalent degree; Postdocs hold a PhD or equivalent degree in any of these or a related field.

PhD students will have the opportunity to participate in one of several available PhD programs, with four years funding and a possibility of extension, in collaboration with the University of Göttingen. Masters students aiming at a fast track PhD are also welcome. The Postdoc position is limited to two years with a possibility of extension.

Payment and benefits are based on the TVöD guidelines. The starting date is flexible.

The Max Planck Society is committed to increasing the number of individuals with disabilities in its workforce and therefore encourages applications from such qualified individuals.

Interested? Submit your application including cover letter (explaining background and motivation), CV, transcripts, and publication record preferably via e-mail as one single PDF file to

ausschreibung06-20@mpibpc.mpg.de

Max Planck Institute for Biophysical Chemistry
Research Group „Computational Biomolecular Dynamics“
Prof. Dr. Bert de Groot
Am Fassberg 11
37077 Göttingen
Germany

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