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Job openings

    30 March 2021

    Lecturer/Senior Lecturer position in London

     

    We  have an open position within the Randall Centre  in Computational Biophysics,

    https://jobs.kcl.ac.uk/gb/en/job/018006/Lecturer-or-Senior-Lecturer-in-Computational-Biophysics

    Go to announcement
      30 March 2021

      Innova XN PhD position in Grenoble,


      ONTEXT & JOB DESCRIPTION

      Project Tile: Nanostructural characterisation of protein interactions with lipid bilayer membranes : basis for biosensor development

      This PhD project is in the field of biosensors based on nanostructured biomimetic tethered lipid bilayers (tBLM) to detect plasma proteins. These proteins are used as biomarkers of severe pathologies including cancer, but their detection is difficult due to their relatively low abundance. Often present in glycosylated form they form complexes with lipids in order to be transported in the blood. A lipidic environment is thus an appropriate environment for a biosensor, also including the capturing antibody, to detect all biomarkers bound to protein/lipid complexes in blood samples. A proof-of-concept biosensor utilising tBLM connected to an Impedance Spectroscopy was developed recently for the detection of a glycosylate protein cancer biomarker soluble VE-cadherin by utilizing a tBLM produced by SDx Tethered Membranes Pty Ltd. The PhD student will perform a nanostructural characterisation of the interaction between peptide and protein biomarkers and tBLM, and will identify the role of the lipid part to modulate the interaction between tBLM and specific peptides and proteins. These fundamental results will provide the basis for biosensors and analytical procedures that can detect scarce biomarker proteins from other high-abundance proteins and from lipidic moieties in blood samples. The biosensors envisaged are based on nanostructured tBLM in which we have optimised the lipid composition for specific proteins interactions.

      Further information may be obtained from Giovanna Fragneto (email:fragneto@ill.fr) and from Marco Maccarini  (email: marco.maccarini@univ-grenoble-alpes.fr), Donald Martin (email: donald.martin@univ-grenoble-alpes.fr)   
       EXPECTED PROFILE

          Degree allowing enrolment for a PhD (such as MSc, Master 2 de Recherche, Laurea or equivalent) in physics, materials science, chemistry or closely related science
          A background in large scale facilities experiments (neutron and x-ray scattering), and knowledge computer programming (C++, Python) would be an advantage
          Ability in handling of biological materials would be an advantage
          Proficiency in English (A proof of upper-intermediate level would be advantageous and can be provided in the application. Applicants originating from native-English-speaking countries can apply without the need for proof of level. An official degree conducted in English will be also accepted as a proof; Students without proof upper-intermediate level may still apply and their level of English will be checked during the interview).
          Compliance with the Marie Sklodowska-Curie mobility rule: candidates may not have resided or carried out their main activity (work, studies, etc.) in France for more than twelve months in the three years immediately before the date of recruitment.
          At the date of recruitment, early-stage researchers must be in the first four years of their research careers and have not yet been awarded a doctoral degree.
          Candidates must satisfy eligibility criteria according to the partner university requirements for PhD enrolment.

      More details about the application procedure on www.innovaxn.eu/for-students/documents/

      WORKING CONDITIONS

      The successful candidate will be enrolled in the doctoral school of Université Grenoble Alpes and based full-time at the ILL (Grenoble, France), other than a 3-month secondment at SDX-membranes (Roseville, Australia). Additional visits totaling no more than 3 months may be made to the University Grenoble Alpes when needed. Furthermore, a varied pedagogical training programme will be offered to the successful candidate throughout the 3-year PhD project.


      Interested candidates can  send an on-line application at the link below:
      https://esrf.gestmax.eu/1482/1/phd-position-nanostructural-characterisation-of-protein-interactions-with-lipid-bilayer-membranes/en_US

      Go to announcement
        30 March 2021

        PhD studentship in Computational Life Sciences

        Please find attached details of a PDRA opportunity at Universitat Autònoma de Barcelona.

        Group for Computational Life Sciences, Division of Physical Chemistry
        at Ruđer Bošković Institute, Zagreb (Croatia) offers a PhD
        studentship. Candidates will be accepted who have completed a study in
        physics or chemistry, mathematics or electronics and computational
        science.

        The doctoral thesis work will be done mostly at the Ruđer Bošković
        Institute in Zagreb under the mentorship of prof.dr. Ana-Sunčana
        Smith, while the student will be enrolled in the doctoral school at
        FAU Erlangen Nürnberg (Germany) and receive a german doctorate (PhD)
        from FAU.

        The research area is open, and includes topics from theoretical
        statistical physics with emphasis on non equilibrium stochastic
        processes, cell and tissue biophysics, applied mathematics and
        computing, and also, modeling of physical and chemical processes of
        active material surfaces.

        The duration of the contract is 4 years. Annual salary is approx.
        17000 EUR (gross) and comprises health insurance, and social/pension
        contributions and also local travel costs to and from work, as per
        Croatian regulations and statutes for employees in science and higher
        education.

        The person will work in an interesting and dynamic international
        environment and work closely with prof. Smith group in Germany.
        Student should expect occasional travel and study stays in Germany and
        continuous training and learning opportunities will be provided.

        Applicants should meet the requirements listed here:
        https://euraxess.ec.europa.eu/jobs/613008

        - university graduate diploma or integrated study diploma in physics,
        chemistry, mathematics or electrical engineering and computer science
        with excellent overall average of grades at previous levels of study
        (undergraduate, graduate or integrated studies) that ensures admission
        to doctoral studies
        - motivation letter in English proving interest in the thesis subject
        of modeling in the field of advanced materials and biophysics

        Additional criteria:
        Rector's award, success in scientific competitions, participation in
        scientific conferences, published scientific papers.

        It is desirable that applicants enclose letters of recommendation.
        More about group activities:
        https://www.irb.hr/eng/Divisions/Division-of-Physical-Chemistry/Group-fo...
        https://www.irb.hr/Zavodi/Zavod-za-fizicku-kemiju/Grupa-za-racunalne-bio...
        www.puls.physik.fau.de

        contact: smith@physik.fau.de


        Deadline for applications is 9.4.2021., 23:00 Brussels time.

         

        Go to announcement
          30 March 2021

          Postdoc Position in Bochum / BRD

          Postdoc Position, Quantifying entropy from protein dynamics by simulation and experiment (full position, TV-L E13/100%)

          Applications are invited for a Postdoctoral Research Fellow position, which is available immediately or upon mutual agreement. The goal of the project is to combine MD simulations and NMR relaxation to obtain atomic-levels insights into the link between protein dynamics and conformational entropy. The project is carried out in collaboration with Professor Frans Mulder at Aarhus University/Denmark and it will involve extended research stays at Aarhus University. The successful candidate has experience in theoretical and computational chemistry, biomolecular simulations, statistical mechanics, structural biology, and scientific computing. Experience in NMR spectroscopy and advanced biomolecular simulation methods, such as e.g. enhanced sampling techniques and force field development, are beneficial but not a requirement. Most important is proven scientific excellence.

          Ruhr University Bochum (RUB) is one of the leading research universities. The university draws its strengths from both the diversity and the proximity of scientific and engineering disciplines on a single, coherent campus. This highly dynamic setting enables students and researchers to work across traditional boundaries of academic subjects and faculties.

          The Center for Theoretical Chemistry at RUB offers an exciting interdisciplinary research environment and excellent facilities including several in-house high-performance computing platforms. The togetherness of different disciplines and their cultures offers excellent opportunities for interdisciplinary collaborations for researchers and students. Bochum offers affordable prices for housing and a broad cultural program.

          If the position is funded by third-party funds the employee has no teaching obligation.

          Candidates should have an excellent M.Sc. (or equivalent) degree in chemistry, physics, or a related field, and a PhD (or equivalent degree) in Theoretical/computational chemistry/(bio-)physics or in NMR spectroscopy. The group language is English, so no German language skills are required – but it’s a great opportunity for you to learn German.

          Interested? Submit your application including cover letter, CV, list of publications, transcripts, and the contact details of at least two persons who would be willing to provide a letter of reference, preferably via e-mail as one single PDF file to:

          Prof. Dr. Lars Schaefer
          Center for Theoretical Chemistry
          Ruhr University Bochum
          D-44780 Bochum, Germany
          lars.schaefer@rub.de | www.molecular-simulation.org

          Travel expenses for interviews cannot be refunded.

          The contract is fixed term. Initial appointment is for 2.5 years. Consideration of candidates will begin immediately.

          At Ruhr University Bochum, we wish to promote careers of women in areas in which they have been underrepresented, and we would therefore like to encourage female candidates to send us their applications. Applications by suitable candidates with severe disabilities and other applicants with equal legal status are likewise most welcome.

          Go to announcement
            30 March 2021

            Senior NMR technical position

            A senior NMR technical position is available to operate the magnetic resonance facility at the Australian National University (ANU) in Canberra.  The facility houses NMR spectrometers (400, 600, 700 and 800 MHz; cryoprobes at 600 and 800 MHz; fast MAS solid-state probes at 700 and 800 MHz) and pulsed EPR (X-band, Q-band, W-band) equipment. It is located in the Research School of Chemistry (RSC) and serves the entire university.

            You will work directly with protein researchers, material scientists and synthetic chemists. Your responsibilities will include the operation and maintenance of the equipment, as well as the implementation of NMR methods and training of users in NMR. The position requires a Ph.D. in chemistry, biochemistry, physics or closely related field. Excellent communication skills are required.

            The successful applicant must have rights to live and work in Australia.

            Queries can be addressed to

            Professor Gottfried Otting

            The Australian National University

            Research School of Chemistry

            Sullivans Creek Rd, Bldg 137

            Canberra ACT 2601, Australia

            phone: +61-2-6125 6507

            email: gottfried.otting@anu.edu.au

            http://rsc.anu.edu.au/~go/index.html

             

            Go to announcement
            • PostDoc
            13 February 2021

            PhD and Postdoc Positions CEITEC Masaryk University, Czec

            PhD positions at the CEITEC Masaryk University, Czec                                         

            Starting:      September 2021
            Duration:     4 years
            Expires:        Applications are considered until the position is filled
            Supervisor: Robert Vacha (robert.vacha@mail.muni.cz)
            Employer:   CEITEC Masaryk University, Czech Rep.


            Postdoc positions

            Starting:      April 2021 or later
            Duration:     2 years
            Expires:        Applications are considered until the position is filled
            Supervisor: Robert Vacha (robert.vacha@mail.muni.cz)
            Employer:   CEITEC Masaryk University, Czech Rep.

            For further information:
            http://vacha.ceitec.cz/jobs-openings/

            1) Selectivity of translocation across lipid membranes

            We have shown that a specific class of transmembrane proteins, called scramblases, can facilitate not only spontaneous flip-flop of lipids but also a translocation of other amphiphilic molecules across cellular membranes. However, we miss information about the selectivity of this transport. The goal of this project is to determine the specificity of scramblase activity and obtain a molecular understanding of the selectivity. The main tool will be Molecular dynamics simulations with free energy calculations.

            2) Synergistic translocation of multiple peptides

            Translocation of peptides across cell membranes is one of the mechanisms by which antimicrobial peptides can kill bacteria. Moreover, such peptides can act as cell-penetrating peptides delivering drug cargos to the cell. Despite the potential of such peptides, their development is hindered by the lack of knowledge about the peptide sequence-to-function relationship. In this project, we will take advantage of peptide synergism, in which peptide mixture is more effective than its components. In particular, the project is focused on the co-translocation of multiple peptides. The main tool will be Molecular dynamics simulations with free energy calculations. Part of the project could take advantage of Monte Carlo simulations with a highly coarse-grained model.

            3) Association of proteins in phospholipid membranes

            A large fraction of membrane proteins forms oligomers. These include receptors, ion channels, and fusion proteins, which association and dissociation control essential cellular processes. In the past, the membrane was viewed as a passive environment, in which the association takes place. Now we know that lipids can play an active role in determining the change of the oligomerization state. However, the interplay between the lipids and protein oligomerization state remains poorly understood. The goal of this project is to calculate the association of selected membrane proteins in the environments of various lipid compositions and determine the key features controlling the oligomerization state. We will do so by Molecular dynamics simulations with free energy calculations.

            Eligibility: Outstanding candidates with experience in computer simulations and with an MSc/PhD degree in the fields of biophysics, soft matter physics, physical chemistry, computational chemistry, statistical mechanics, or related fields. Experience with molecular dynamics simulations (with GROMACS, CHARMM, NAMD, AMBER, LAMMPS, etc.) or other simulation techniques (Monte Carlo, DPD, etc.) at the atomistic or coarse-grained level would be an advantage.

            Computing Resources: Successful candidates will have access to local computing clusters with 2500 cores and 100 GPUs. Access to Metacentrum NGI – National Grid Infrastructure for computing (with ~20,000 cores) will be also available. Additional resources include the possibility of applying for IT4Inovations, where the group is active.

            Competitive salary: depending on the position - supported by grant projects including ERC consolidator grant.

            Application procedure: Applications must include a CV, with list of publications and study results, short personal statement (description of research interests, past, and plans), and the name of a person willing to provide a letter of recommendation. Applications with all this material (preferably in a single pdf) should be sent to Robert Vacha (robert.vacha@mail.muni.cz).
            Why join us?

                International opportunities – CEITEC is a leading member of Alliance 4 Life, a member of the EU Life consortium, in strategic partnership with The Vienna Biocenter Core Facilities
                Wide career options
                Build connections via our international partnerships and events (47% of publications created within the international cooperation)
                Transferable skills courses, cooperation with industry
                Brno is EU & NATO member and voted 4th best city for students’ life
                An international community with frequent informal events
                Top score in Quality of life index in 2020

            Institute:

            CEITEC is a scientific centre in the fields of life sciences, advanced materials and technologies whose aim is to establish itself as a recognized centre for basic as well as applied research. CEITEC offers a state-of-the-art infrastructure and great conditions to employ excellent researchers. Our institute values diversity and promotes an inclusive working environment with the aim to support the best scientists. CEITEC MU is a proud holder of the HR Excellence in Research Award by the European Commission.

            Go to announcement
            • Postdoctoral Fellow Position in Liverpool
            13 February 2021

            5 PhD Fellowships in Physics and Chemisty,, Trieste Italy

            International School for Advanced Studies, Trieste                                                                            

            There are 5 positions available for the PhD in "Physics and Chemistry of Biological Systems" at the International School for Advanced Studies (SISSA), Trieste, Italy.

            The application deadline is March 16, 2021, for both EU and non EU students

            Students are expected to join the written and oral exam on March 29 and 30. The exam will be held remotely.

            Applicants should have a good background in Physics, Chemistry, Applied Mathematics or related subjects and are expected to obtain their Laurea Specialistica or equivalent degree by Autumn 2021.

            The application can be done online at this link:
            https://pica.cineca.it/sissa/phd-physchem-01-2021/

            Admitted students will have the opportunity to follow a one-year educational program in an international and interdisciplinary environment, followed by three years of active research in one of the following areas:

                Structural bioinformatics
                Statistical mechanics of complex molecular systems
                Biomolecular simulations
                Simulations of rare events
                Data science of complex and biomolecular systems
                Polymer physics
                Active matter

            For further information about the available research lines and past entrance exams see:
            http://www.sissa.it/sbp/phdsection/entranceexam.php
            and related webpages.

            Go to announcement
            • PostDoc
            13 February 2021

            2 PostDoc Positions, Linz, Austria

            Two PostDoc Positions
            in single-molecule microscopy

            The world is changing at an ever-faster pace. At the Johannes Kepler University Linz, we work on technologies and the ideas of tomorrow on a daily basis. At the same time, we educate over 21,000 young people to meet the demands of today’s job market. In short, we are Upper Austria’s largest institution for education and research. Are you interested in being a part of shaping the future of Austria’s most attractive campus university? We currently have two immediate job openings for:
            PostDocs (must hold a Doctorate/Ph.D. degree)
            (i) for a full-time, six-year position
            (ii) for a full time, 20 months position
            at the Institute of Biophysics, Department of Molecular and Membrane Biophysics

            Job Duties:
            • Research: Contribute to research activities and publications within the Pohl group’s research foci
            • Education: Assist in teaching university-level courses offered by the institute (mandatory only for the 6 year-position)
            Your Qualifications:
            • The successful candidate must hold a Doctorate/Ph.D. in the field of Physics/Biophysics or equivalent qualification
            • Strong command of English (level C1)
            • Expertise in a programming language
            • Experience in setup and application of highly-sensitive light microscopic techniques, preferably fluorescence
            single-molecule microscopy
            • Knowledge of fluorescence correlation spectroscopy is desirable
            • Working experiences with planar and vesicular model membranes and in electrophysiology are advantageous
            • Commitment, responsibility, communication and critical thinking skills, team spirit and ambition
            What We Offer:
            • On the basis of full-time employment (40 hours/week) the minimum salary in accordance with the collective agreement is € 3,945.90 gross per month (14 x per year, CA Job Grade: B1)
            • Stable employer
            • Attractive campus environment with good public transportation connections
            • Attractive continual educational opportunities
            • State-of-the-art research infrastructure
            • Dynamic research environment
            • Broad range of on-campus dining services/healthy meals (organic food at the cafeteria)
            • Exercise and sports classes (USI)
            • …and much more
            Application Deadline: February 10, 2021.
            The Johannes Kepler University wishes to increase the proportion of academic female faculty and, for this reason, especially welcomes applications by qualified women. If applicants are equally qualified, a woman will be given preference for this position. The university welcomes applications from qualified applicants with physical disabilities. These applications will be given special consideration.
            How to Apply:
            Prospective applicants interested in the multifaceted position are requested to electronically send an application in adherence to the stated criteria together with the requested documentation via our online portal jku.at/application or to the Johannes Kepler University Linz, Department of Human Resource Management, Altenberger Straße 69, A-4040 Linz. Please include “Job Reference Number 4411“ in your application.
            Contact:
            If you have questions, please contact: Univ. Prof. Dr. Peter Pohl, P +43 732 2468 7562, E mail: peter.pohl@jku.at.

            Go to announcement
            • PhD
            13 February 2021

            Research Associate at Liège

            Facility manager at the University of LiègeThe  Centre  for  Protein  Engineering  (CIP)  at  the  Université  de  Liège  is offering  a positionfor  a research  associate  in  the  fields  of  biochemistry,  molecular  biologyand biotechnology.  He  or  she  will  be  the  manager  of  the  Robotein®facility  (Liège  site)(http://www.robotein.ulg.ac.be/), which is dedicated to high-throughput protein production and analysis. This  platform,  which  has  recently  been  added  to the  Instruct-ERIC  catalogue(https://instruct-eric.eu/centres/instruct-be/), offers    automated    screening    for    optimal recombinant protein expression, purification and formulation, together with biochemical and biophysical protein analysis.The position is initially for one year and is based in the Department of Life Sciences and the InBioS research unit, in the Faculty of Sciences.It offers opportunities for  scientific  collaboration  at  the  national  and  international  level,  both  with  academic  and industrial partners, and enables an ambitious candidate to play an important role in the shaping of the future development of the facility as a flagship of the Institution. Agood  knowledge  and  technical  expertise  in  the  fields  of  protein  production  and analysis, with particular emphasis on protein-ligand interactions, are expected.The candidatewill play  an  important  rolein  the  development  of  existing  or  new  protocols  for  the characterization of proteins. Furthermore, the applicant willalsobe expected to demonstrate managerial skills, including meetings with collaborators or clients,hosting of Instruct-ERIC visitors,administrative  duties,  maintenanceand  accountingwork,and  organisational management. Applicants need to be confident in developing new technological tools for the advancement of Robotein®, in particular within the frame of its new partnership with Instruct-ERIC, which aimsatfacilitating important scientific breakthroughs.Theposition offersan  exciting  opportunity  to  make  a  major  contribution  to  the development ofaninternationallyacknowledgedplatform,while allowing you to progress and enxpandyour scientific knowledge and network.Contact:  Professor  André  Matagne  (amatagne@ulg.ac.be),  coordinator  of  Robotein®and chair of the Centre for Protein Engineering

            Go to announcement
              13 February 2021

              Senior NMR technical Position Canberra

              Senior NMR technical Position Australia                                                                                                                                                        

              A senior NMR technical position is available to operate the magnetic resonance facility at the Australian National University (ANU) in Canberra.  The facility houses NMR spectrometers (400, 600, 700 and 800 MHz; cryoprobes at 600 and 800 MHz; fast MAS solid-state probes at 700 and 800 MHz) and pulsed EPR (X-band, Q-band, W-band) equipment. It is located in the Research School of Chemistry (RSC) and serves the entire university.

              You will work directly with protein researchers, material scientists and synthetic chemists. Your responsibilities will include the operation and maintenance of the equipment, as well as the implementation of NMR methods and training of users in NMR. The position requires a Ph.D. in chemistry, biochemistry, physics or closely related field. Excellent communication skills are required.

              The successful applicant must have rights to live and work in Australia.

              Queries can be addressed to

              Professor Gottfried Otting

              The Australian National University

              Research School of Chemistry

              Sullivans Creek Rd, Bldg 137

              Canberra ACT 2601, Australia

              phone: +61-2-6125 6507

              email: gottfried.otting@anu.edu.au

              http://rsc.anu.edu.au/~go/index.html

              Go to announcement

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