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    29 July 2021

    Group Leader Positions at ANU /Canberra

    We are currently advertising  for three new group leaders at the Research School of Biology at the ANU (Research School of Biology). One of the positions is designated in membrane biology and would suite someone studying membranes, ion channels or other membrane proteins.

    For further information take a look at:https://jobs.anu.edu.au/cw/en/job/540890/group-leader

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      29 July 2021

      3-4 Postdoctoral Scientists + PhD Students / Helsinki

      Our computational team in the University of Helsinki is looking for outstanding candidates with experience in computer simulations, and who have recently obtained PhD (postdoc positions) or MSc (PhD student positions) degrees in fields of biological physics, biophysics, soft matter and stat mech, (bio)physical chemistry, machine learning, computational drug design and discovery, or related fields. Experience with molecular dynamics simulations (with GROMACS, NAMD, etc.) and other simulation techniques (DFT, QM/MM, DPD, SRD, LB, etc.) on atomistic and coarse-grained levels is considered an asset.

      We are aiming to hire 3-4 new members to our team.

      The projects will focus on membrane-associated receptors/proteins with an objective to understand how their dynamics and activation are modulated, how impairment of these modulation mechanisms compromises the function, and how it can be rectified. The proteins in question are involved in abundant diseases that include type 2 diabetes, mitochondrial diseases, neurodegenerative disorders, and impairment of the biological barrier function related to lung function impairment (ARDS, Covid-19, etc.). The research is strongly coupled to collaborations with several first-class experimental teams.

      Details including instructions to apply are given in the attached PDF.

      Please feel free to forward the information to your group members and colleagues.With best wishes, IlpoProf. Ilpo VattulainenBiological Physics GroupDept of Physics, University of Helsinki, Finland

      E-mail: Ilpo.Vattulainen@helsinki.fi

      Mobile:  +358 400 510 592

      Web: https://www.helsinki.fi/en/researchgroups/biophysics (Our group)

      Web: http://prolipids.helsinki.fi (Center of Excellence in Biomembrane Research)

      Web: https://www.helsinki.fi/en/researchgroups/helsinki-eye-lab (Helsinki Eye Lab)

      Go to announcement
        29 July 2021

        Computational structural Biologist / Cambridge

        We are seeking a highly motivated and skilled Computational Structural Biologist with experience in developing structural bioinformatics tools/pipelines to join Lonza's Applied Protein Services (APS) Bioinformatics team based in Cambridge, UK.

        To apply:
        https://www.lonza.com/jobs/R33311

        Daphné Truan, PhD Senior Group Leader
        APS Bioinformatics

        Lonza Biologics
        Chesterford Research Park
        Cambridge, United Kingdom
        www.pharma.lonza.com



         

        Go to announcement
          28 July 2021

          5 PhD Fellowships in Physics and Chemistry, Italy

          There are 5 positions (4 assigned, 1 STILL AVAILABLE) for the PhD in "Physics and Chemistry of Biological Systems" at the International School for Advanced Studies (SISSA), Trieste, Italy.

          THE APPLICATION DEADLINE IS AUGUST 25, 2021, FOR BOTH EU AND NON EU STUDENTS

          Students are expected to join the written and oral exam on September 6 and 7. The exam will be held remotely.

          Applicants should have a good background in Physics, Chemistry, Applied Mathematics or related subjects and are expected to obtain their Laurea Specialistica or equivalent degree by Autumn 2021.

          The application can be done online at this link:

          https://pica.cineca.it/sissa/phd-physchem-02-2021/

          Admitted students will have the opportunity to follow a one-year educational program in an international and interdisciplinary environment, followed by three years of active research in one of the following areas:

                    * Structural bioinformatics

                    * Statistical mechanics of complex molecular systems

                    * Biomolecular simulations

                    * Simulations of rare events

                    * Data science of complex and biomolecular systems

                    * Polymer physics

                    * Active matter

          For further information about the available research lines and past entrance exams see:

          http://www.sissa.it/sbp/phdsection/entranceexam.php

          and related webpages.


           

           

           

          Go to announcement
            28 July 2021

            Postdoctoral Research Associate, New York City

            The Filizola Lab Filizola Laboratory | Computer-Aided Structural Biology and Drug Design at the Icahn School of Medicine at Mount Sinai, in New York City, USA is inviting applications for a postdoctoral research associate position in the broad field of computer-aided drug discovery. The laboratory is best known for contributing rigorous mechanistic insight into the structure, dynamics, and function of prominent drug targets such as G protein-coupled receptors (GPCRs), transporters, channels, transcription factors, and b3 integrins, for the ultimate purpose of accelerating drug discovery. To this end, we use several computational structural biology, cheminformatics, and artificial intelligence (AI)-based approaches, including molecular dynamics simulations, enhanced sampling methods, machine learning, deep learning, free-energy perturbations, molecular modeling, etc. Current ongoing projects include: discovery of novel chemotypes for a variety of prominent drug targets, binding and optimization of atypical opioid drugs, structure-based prediction of the efficacy of proteolysis-targeting chimaeras (PROTACs) for selective protein degradation, understanding functional selectivity of GPCRs at an atomic level of detail, predicting drug-target residence times as better indicators of in vivo drug efficacy than binding affinity, integrative structural modeling of intermediate conformations of ligand-protein complexes along protein’s activation pathway(s), etc.
             
            The ideal candidate should have a Ph.D. or equivalent degree in a quantitative science major, including but not limited to Physics, Chemistry, Biophysics, Bioinformatics, Theoretical/Computational Chemistry, Computational Biology, Computer Science, Engineering, or a related discipline. To qualify for this position, a strong analytical ability is required alongside expert programming skills and a solid knowledge of molecular dynamics simulations, free energy calculations, machine learning/deep learning, Markov State Models, virtual screening, docking, pharmacophore analysis, etc. Strong communication skills and an ability to both collaborate with peers and train junior colleagues effectively are also required. The position is available immediately. 

            Qualified applicants should send a CV and at least 2 reference names by email to Dr. Marta Filizola at marta.filizola@mssm.edu

            Review of applications will begin immediately and continue until the position is filled. 

            Go to announcement
              05 July 2021

              Post-doctoral Training and Research in Biology Wisconsin

              Post-doctoral Training and Research in Computational Biology
              University of Wisconsin-Madison https://wid.wisc.edu/

              The Yin Lab at the University of Wisconsin-Madison (wid.wisc.edu) has an immediate opening at the postdoctoral level to pursue projects in computational biology at the interface between mechanistic modeling and machine learning. NIH and NSF funded projects span diverse application areas that include bio-electronic medicine (lower urinary tract dynamics and control), multi-scale modeling (molecular-to-cellular, tissueto-organ), and virus-cell interactions and dynamics (including coronavirus). The position 
              also provides opportunity to train for a career in inclusive teaching and research mentoring (delta.wisc.edu). Members of historically underrepresented groups in science and engineering are especially encouraged to apply. 
              Applicants should have earned a Ph.D. in biophysics, engineering, statistics, math, computer science, or a related field. Strong analytical, quantitative, and programming skills, as well as proficiency in machine learning, are essential. Further requirements include: ability to effectively collaborate, work independently, meet deadlines, initiate and complete tasks without close supervision, and conduct independent analyses of qualitative and quantitative data. 
              Earliest Start Date: July 1, 2021 
              Percent Time: 100%
              Salary: NIH post-doctoral level 
              To apply: 
              send by email (subject: post-doc opening) a CV and coverletter with contact info for 3 references to John Yin (mail to  john.yin@wisc.edu).

               

               

               

               

               

               

               

               

               

              Go to announcement
                05 July 2021

                Job Opportunities in Oxford Start-Up

                XAI-BiO is a deep-tech therapeutics discovery and development startup based in Oxford. We’re currently recruiting for two positions, which are most suitable for people in your research group: 1) Quantitative Biologist,  2) Computational Systems Biologist. 

                Biology today is where information technology was 50 years ago. We are entering a new era. If you aspire to be at the cutting-edge of biology by engineering medicines through biological engineering, then we want to hear from you. You have the opportunity to become an integral part of our foundational team and influence the Company’s development.We’re looking to recruit a computational systems biologist and a quantitative biologist. The deadline is Friday 9 July 2021.

                Offene Stellen bei XAI.bio (breezy.hr)


                Sarah A Harris
                Lecturer in Biological Physics
                School of Physics and Astronomy
                University of Leeds,UK

                Go to announcement
                  05 July 2021

                  PhD Position, Technologies in Zebrafish, Innsbruck

                  At the Institute of Molecular Biology of the University of Innsbruck, we are recruiting a PhD student to participate in an exciting interdisciplinary project embedded within an international EU-funded consortium.
                  The project SWIMMOT 

                  www.swimmot.researchproject.at/index.htm

                  aims to develop innovative molecular imaging methods based on switchable contrast agents combined with magneto-plasmonic imaging. The Innsbruck contribution to the project encompasses application of the novel visualization modalities in the model organism zebrafish to elucidate pancreatic beta cell biology and illuminate progression of diabetesassociated retinal complications.
                  The research group is focused on studying beta cell function and diabetes in the vertebrate model organism zebrafish. We use genetic disease models, modern molecular biology approaches, and innovative imaging and analysis methods.
                  Desired Qualifications:
                  • Master’s degree in biomedical sciences, bioengineering, or similar 
                  • Experience with molecular biology and imaging is essential
                  • Previous work in imaging/microscopy, biophysics, and/or biomaterials is highly desirable.
                  • Previous experience with laboratory animal models, especially zebrafish, is preferred
                  • Applicants should have good communication skills and be fluent in English
                  We offer a dynamic, friendly, and international working environment in the heart of the Alps. The 
                  Leopold-Franzens University of Innsbruck is the largest research and education institution in western 
                  Austria, with more than 28,000 students and 4,500 staff and faculty members. The University of 
                  Innsbruck offers excellent facilities for research in a spectacular environment.
                  Interested applicants should submit the following information: a motivation letter, CV including
                  publication list, a summary of your previous research experiences, grades of Bachelor and Master 
                  studies and the contact information for 2-3 references. 


                  Submit to Dr. Robin Kimmel: robin.kimmel(at)uibk.ac.at

                   

                  Go to announcement
                    05 July 2021

                    PhD Position University of Vienna

                    available PhD position: “Characterisation and rescue of ion channel and Ca handling abnormalities in dystrophin-deficient cardiomyocytes”

                    Duchenne muscular dystrophy (DMD), caused by mutations in the dystrophin gene, is an inherited disease characterized by progressive muscle weakness and degeneration. Besides the relatively well described skeletal muscle degenerative processes, DMD and some other muscular dystrophy types are also associated with cardiovascular complications including cardiomyopathy development and cardiac arrhythmias. The current understanding of the patho-mechanisms underlying the cardiac complications is still very limited, but recent research points to dysfunctional ion channels and abnormal Ca handling in dystrophic cardiomyocytes.

                    In the present project we will study abnormalities in ion channel function and Ca handling in the dystrophic heart. Therefore, ventricular cardiomyocytes and Purkinje fibers will be isolated from the hearts of mouse models of DMD. The major aims are:
                    1) detailed characterisation of ion channel and Ca handling abnormalities in adult dystrophic myocytes and Purkinje fibers, and
                    2) exposure of the mechanism(s) underlying these abnormalities. In a second step, we will try to rescue dystrophic ion channel and Ca handling abnormalities by gene therapy strategies using adeno-associated virus vectors in DMD mouse models.

                    Together these studies should elaborate ion channel and Ca handling abnormalities as significant disease mechanisms, and thus therapeutic targets to inhibit dystrophic cardiomyopathy development and to improve arrhythmia management in DMD patients.

                    We are looking for a PhD candidate with a strong interest in cardiac physiology, electrophysiology, and pharmacology. The methods applied in our group comprise: electrophysiology (i.e. the patch clamp technique), isolation of ventricular cardiomyocytes and Purkinje fibers from mouse hearts, human iPSC- derived cardiomyocytes, intracellular Ca measurements, muscular dystrophy mouse models, cell culture, standard biochemistry and molecular biology. Previous experience with the listed methods (especially electrophysiology!) will be considered as advantage. Excellent written and oral English language skills are essential, as well as high accuracy, reliability and good interpersonal skills. The PhD candidate will be enrolled in the PhD program “Molecular Signal Transduction” and is required to have a Diploma or a Masters’ Degree in medicine, biochemistry, biology, chemistry or a related subject.

                    Please send your application (pdf) including a short C.V., brief statement of previous experience and the contact details of at least two referees via e-mail to Karlheinz Hilber. The position will be available as of July/August 2021 in the group of Assoc. Prof. Karlheinz Hilber at the Center for Physiology and Pharmacology, Medical University of Vienna.

                    Contact: Assoc. Prof. Dr. Karlheinz Hilber
                    Email: karlheinz.hilber@meduniwien.at
                    Phone: +43-1-40160-31230

                    Offene Stellen | MedUni Wien

                    Zentrum für Physiologie und Pharmakologie | Über die MedUni Wien

                     

                    Go to announcement

                      Open PhD and Postdoc positions in Theoretical and Computational Biophysics at the Max-Planck Institute for Biophysical Chemistry (MPI-BPC), Gottingen, Germany

                       

                      The Department of Theoretical and Computational Biophysics, headed by Helmut Grubmüller, and the Research Group Computational Biomolecular Dynamics, headed by Bert de Groot, are looking for people interested in contributing to one of the following projects as PhD Student or Postdoc:

                       Grubmüller Lab

                      ·         Theory and Algorithms for Structure Determination from Ultrafast Single Molecule X-FEL Diffraction and Fluctuation Correlation X-Ray Scattering Experiments

                       De Groot Lab

                      ·         Interactions of focused ultrasounds with lipid membranes and ion channels

                      ·         Pharmacological regulation of potassium channels

                      ·         Combined computational alchemy and deep learning for:

                      o   ligand design and optimisation for drug development

                      o   mutation scans in protein design and drug resistance

                       

                      Please visit the department or group websites for further details on the requirements and projects:

                      https://www.mpibpc.mpg.de/grubmueller

                      https://www3.mpibpc.mpg.de/groups/de_groot/

                      We’re also on Twitter: https://twitter.com/CompBioPhys

                      05 July 2021

                      PhD Student or Postdoc Max Planck Institute Göttingen

                      The Max Planck Institute for Biophysical Chemistry is one of the largest institutes of the Max Planck Society for the Advancement of Science and conducts basic research to advance knowledge and benefit society. Innovative projects and interdisciplinary cooperation characterize research within the Max Planck Society. 
                      The Department of Theoretical and Computational Biophysics (Prof. Dr. Helmut Grubmüller) invites applications for a position as PhD Student or Postdoc (f/m/d) 
                      (Code number 19-21)
                      for the project 
                      Theory and Algorithms for Structure Determination from Ultrafast Single Molecule 
                      X-FEL Diffraction and Fluctuation Correlation X-Ray Scattering Experiments 

                      The aim is to develop Bayesian methods to obtain high-resolution molecular structures and dynamics from sparse and noisy experimental data. A particular focus is to develop accurate uncertainty models to be included within the probabilistic approach. 
                      More details: www.mpibpc.mpg.de/9660732/SM-Ultrafast-XRay-Diffraction

                      The successful candidate has a keen interest and strong skills in computational physics and probability theory, and also a strong interest in interdisciplinary research and collaboration with experimental groups. 
                      PhD candidates hold (or expect to complete soon) a Masters or equivalent degree; Postdocs hold a PhD or equivalent degree in any of these or a related field. 
                      PhD students will have the opportunity to participate in one of several available PhD programs, with four years funding, in collaboration with the University of Göttingen. Masters students aiming at a fast track PhD are also welcome. The Postdoc position is limited to two years with a possibility of extension. 
                      Payment and benefits are based on the TVöD guidelines. The starting date is flexible. 
                      The group language is English, so no German language skills are required – but it’s a great opportunity for you to learn German! 
                      The Max Planck Society is committed to increasing the number of individuals with disabilities in its workforce and therefore encourages applications from such qualified individuals. The Max Planck Society strives for gender and diversity equality. We welcome applications from all backgrounds. 
                      Interested? Submit your application including cover letter (explaining background and motivation), CV, transcripts, and publication record preferably via e-mail as one single PDF file to 

                      ausschreibung19-21@mpibpc.mpg.de
                      Max Planck Institute for Biophysical Chemistry 
                      Department „Theoretical and Computational Biophysics“
                      Prof. Dr. Helmut Grubmüller
                      Am Fassberg 11 
                      37077 Göttingen 
                      Germany 

                      Web: www.mpibpc.mpg.de/grubmueller

                      Information pursuant to Article 13 DS-GVO on the collection and processing of personal data 
                      during the application process can be found on our website below the respective job advertisement

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