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  • PhD

Trieste, Italy
15 January 2020
 

15 January 2020

PhD in Physics and Chemistry of Biolog. Systems

There are 5 positions available for the PhD in "Physics and Chemistry of Biological Systems" at the International School for Advanced Studies (SISSA), Trieste, Italy.

The application deadline is January 21, 2020 for non EU students and March 3, 2020, for EU students

Students are expected to join the written and oral exam on March 25. Non EU students might be selected directly with a Skype interview or might receive a fellowship to be invited to participate to the written exam. See below for contributions towards traveling expenses.

Applicants should have a good background in Physics, Chemistry, Applied Mathematics or related subjects and are expected to obtain their Laurea Specialistica or equivalent degree by Autumn 2020.

The announcement can be found here:

https://www.sissa.it/sbp/phdsection/phd.php

Notice that SISSA can cover, in full or in part, the expenses of students who, after the first screening based on CV and letters of presentations, are admitted to the local entrance exam. Please contact mailto:bussi@sissa.it for further information.

Admitted students will have the opportunity to follow a one-year educational program in an international and interdisciplinary environment, followed by three years of active research in one of the following areas:
•    Structural bioinformatics
•    Statistical mechanics of complex molecular systems
•    Self-assembly
•    Biomolecular simulations
•    Simulations of rare events
•    Data science of complex and biomolecular systems
•    Polymer physics
•    Bayesian statistical models applied to high-dimensional biomedicine (data science fellowship)
One of the 5 positions is bound to the data science project.

For further information about the available research lines and past entrance exams see:
http://www.sissa.it/sbp/phdsection/entranceexam.php
and related webpages.

You can also find a flyer at this link:

https://www.sissa.it/sbp/phdsection/flyer_sbp_2020.pdf

 

 

 

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  • PhD

Bristol University, UK
15 January 2020
 

15 January 2020

(Senior) Scientist Structure based Protein Engineer Lonza

(Senior) Scientist - Structure-based Protein Engineer Lonza - Cambridge UK 

Today Lonza is a global leader in life sciences. We are more than 15,000 employees in more than 100 locations around the world. While we work in science, there’s no magic formula to how we do it. Our greatest scientific solution is talented people working together, devising ideas that help businesses to help people. In exchange, we let our people own their careers. Their ideas, big and small, genuinely improve the world. And that’s the kind of work we want to be part of. 
We are seeking a highly motivated and skilled (Senior) Scientist with experience in Structure-based Protein Engineering and Bioinformatics to join Lonza's Applied Protein Services (APS) Bioinformatics team based in Cambridge, UK. 

Key responsibilities: 
•    The successful candidate will work on multiple customer projects focusing on in silico assessments and computational design of diverse proteins. 
•     You will gain experience on our proprietary platforms for antibody humanisation and deimmunisation, immunogenicity (Epibase) and manufacturability risk assessments to enhance the developability of potential biotherapeutics. 
•    The role involves working with customers ranging from small biotech to big pharma. 
•     Additionally, you will contribute to the development of innovative technologies to 
optimize proteins for the manufacturing processes. Key requirements: 
•    PhD or equivalent in Structural Biology, Chemistry, Physics or Bioinformatics preferably with experience in industry. 
•    Highly experienced in protein structural analysis with emphasis on homology modeling and protein structure-based design. Strong understanding of molecular interactions is essential. 
•    Familiar with biomolecular simulation techniques, including molecular dynamics. 
•    Experienced working in Linux environment and scripting (knowledge of Python is 
essential; Perl is an advantage). 
•    Ability to generate high quality reports and promote effective communication with 
the customer. 
•    Advanced analytical and critical problem-solving skills, combined with scientific 
creativity. 
•    Interest in continuous improvements of processes by integrating innovative 
solutions. 
•    Ability to work as a team member, as well as independently with minimal 
supervision. 
•    Fluency in written and oral English, and strong, written, oral communication skills. 
People come to Lonza for the challenge and creativity of solving complex problems and developing new ideas in life sciences. In return, we offer the satisfaction that comes with improving lives all around the world. The satisfaction that comes with making a meaningful difference. 

To apply: : https://tinyurl.com/qwjuqyg

 

 

 

 

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  • PhD

New York, USA 

15 January 2020

Postdoc Position in Biomolecular Simulations

Applications are invited for a postdoc position in the Filizola Lab (http://www.filizolalab.org) at the Icahn School of Medicine at Mount Sinai, in New York City, USA. We are seeking highly qualified candidates with
expertise and a strong publication record in the development and/or application of computational biophysics/chemistry tools, ranging from molecular dynamics simulations, enhanced sampling algorithms, free 
energy calculations, and machine learning approaches for drug discovery and development. The position will allow participation in a variety of interdisciplinary projects, offering an opportunity to work hand in 
hand with experimental collaborators. 
 
The ideal candidate should have a Ph.D. degree in Physics, Chemistry, Biophysics, Theoretical/Computational Chemistry, Chemical Engineering, or related discipline. He/she should also have expert programming skills and analytical abilities in addition to a strong background in molecular dynamics simulation methods and advanced knowledge of artificial intelligence-based tools to efficiently analyze large simulation datasets. Proven expertise in computational approaches for drug design (e.g., ligand-based and structure-based drug design, virtual screening, docking, pharmacophore analysis etc.) is also appreciated. Strong communication skills, and an ability to both collaborate with peers and train undergraduate students effectively are required. The position is available immediately.  
 
Qualified applicants should send a CV and at least 2 reference names by email to Dr. Marta Filizola at marta.filizola@mssm.edu


Review of applications will begin immediately and continue until the position is filled.
 
___________________________________________
Marta Filizola, Ph.D.
Dean, Graduate School of Biomedical Sciences
Sharon & Frederick A. Klingenstein-Nathan G. Kase, MD Professor
Department of Pharmacological Sciences, Department of Neuroscience  
Icahn School of Medicine at Mount Sinai (ISMMS)
Mailbox: One Gustave L. Levy Place - Box 1677, New York, NY 10029-6574
Office location: 1425 Madison Ave - Room 16-20F
Filizola Lab Website; 212-659-8690; Twitter; LinkedIn; Researchgate

 

 

 

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  • PhD

University of Technology, Graz
13. November 2019
 

13 November 2019

Interdisciplinary PhD positions at TU Graz

PhD positions at the Institute of Biochemistry

The Institute of Biochemistry at the Graz University of Technology is looking for three highly motivated PhD candidates with a genuine interest in understanding molecular mechanisms of biochemical processes.

One PhD position is available as a university assistant position involving teaching and research activities in the group of Peter Macheroux. The research project will have a focus on developing highly specific inhibitors of chorismate synthase, the last enzyme of the common shikimate pathway toward the biosynthesis of aromatic compounds, such as phenylalanine, tyrosine and tryptophan. Toward this goal, we will attempt to determine the structure of the enzyme in complex with lead structures to gain insight into the interaction with amino acid residues in the active site in order to improve the affinity of potential inhibitors. This project will be carried out in collaboration with Andreas Winkler (structural biology) and Rolf Breinbauer at the Institute of Organic Chemistry (organic synthesis of inhibitors). The ultimate aim of the project is the development of therapeutically useful drugs targetting chorismate synthase (1,2).

A FWF-funded PhD position is available in the research group of Gustav Oberdorfer. The groups primary research interests are designing and engineering of biomolecular structures and their function - a multi-facetted effort that combines computational biology, structural biology, biochemistry and biophysics (3, 4). The PhD project will be part of a small local research consortium combining three different disciplines of modern life sciences. In an effort to integrate protein design with optogenetics (group of Andreas Winkler) and tumor immunology (group of Julia Kargl) the successful candidate will employ light responsive dimerization modules to design, engineer and test modern anti-cancer drugs. More specifically, the goal will be to design light-regulated heterodimerization modules that can be linked to different single chain antibodies that would enable T-cell mediated tumor killing with high temporal and spatial precision.

The third PhD position is available in the research group of Andreas Winkler. Objectives in this group revolve around an integrative structural biology approach addressing mechanisms of signal transduction in natural light-regulated enzymes. Understanding principles of sensor-effector modularity and how nature adapts them for diverse requirements, is key to improve success rates of artificial designs for the generation of novel optogenetic tools. In this project, the focus will be set on combining biochemistry and various tools of structural biology (crystallography and hydrogen-deuterium exchange coupled to mass spectrometry) including local collaborations in NMR (Tobias Madl) and cryo-EM (Tea Pavkov-Keller) to address the functional role of structural asymmetry in bacterial red-light photoreceptors (5, 6). Eventually, appreciation of molecular details of structural asymmetry will be helpful for a more rational approach to the design of artificial light regulated functionalities.

All projects provide in-depth, interdisciplinary training in biomedical and biotechnological research in an international and stimulating environment. The thesis projects follow an integrative approach and combine structural biology, enzymology, computational protein design and biophysics to decipher biosynthetic pathways, molecular mechanisms of catalysis and development of biomedical tools, employing a wide range of cutting-edge techniques.

Applicants must hold (or be close to obtaining) an undergraduate degree equivalent to a Master in any discipline of natural, life sciences or computer sciences. The ability to work in a team, initiative, flexibility as well as good organizational and learning skills are required. The selection procedure, all training activities and communications will be in English. Thus, excellent written and spoken English skills are required. Successful applicants will get employed for up to four years (initial contract for one year with the option of prolongation upon successful performance) with a contract that includes social benefits.

Interested applicants should send a motivation letter, CV, one-page summary of their research experience and contact details of two potential referees until the 9th of December 2019 to 

office.ibc@tugraz.at

Prospective starting dates throughout 2020 can be discussed upon acceptance.

References: 1 – Rodrigues-Vendramini F A V, Marschalk C, Toplak M, Macheroux P, Bonfim-Mendonca P, Svidzinski T I E, Seixas F A V, Kioshima E S. (2019) Promising new antifungal treatment targeting chorismate synthase from Paracoccidioides brasiliensis. Antimicrobial Agents & Chemotherapy 63:1-14. 2 – Bueno P S A, Rodrigues-Vendramini F A V, Toplak M, Macheroux P, Kioshima E S, Seixas F A V. (2019) New inhibitors of chorismate synthase present antifungal activity against Paracoccidioides brasiliensis. Future Microbiology 14:969-980. 3 - Oberdorfer G, Huang P-S, Xu C, Pei X Y, Nannenga B L, Rogers J M, DiMaio F, Gonen T, Luisi B, Baker D. (2014) High thermodynamic stability of parametrically designed helical bundles. Science 346 (6208): 481-485. 4 - Boyken S E, Chen Z, Groves B, Langan R A, Oberdorfer G, Ford A, Gilmore J M, Xu C, DiMaio F, Pereira J H, Sankaran B, Seelig G, Zwart P H, Baker D. (2016) De novo design of protein homo-oligomers with modular hydrogen-bond network–mediated specificity. Science 352 (6286): 680-687. 5 - Gourinchas G, Etzl S, Göbl C, Vide U, Madl T, Winkler A. (2017) Long-range allosteric signaling in red light–regulated diguanylyl cyclases. Sci Adv 3 (3), e1602498. 6 - Gourinchas G, Heintz U, Winkler A. (2018) Asymmetric activation mechanism of a homodimeric red light regulated photoreceptor. eLife 7, e34815.

 

 

 

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  • PostDoc

Strasbourg University
6. November 2019

 

06 November 2019

Postdoctoral Position in Strasbourg

Postdoctoral Position: Biophysics of Membrane Polypeptides or Fibers
 
The laboratory Membrane Biophysics and NMR at the University of Strasbourg has an opening for a postdoctoral position with experience in using biophysical techniques for the analysis of peptides and proteins associated with membranes or with fibers. The aim of the project is to reveal the structural determinants that define lipid recognition in membranes and to characterize changes in structure, dynamics, oligomerization and topology of the protein as well as the lipids during recognition. Another ongoing project is the structural investigation of peptide fibers with strong nucleic acid and lentiviral transfection potential.

Candidates should have good experience in biophysical methods used during the investigation of membranes.
Techniques of the laboratory include biomolecular solid-state NMR, solution NMR approaches, optical methods, light scattering, ITC, peptide synthesis and/or the biochemical production of proteins. The candidate should have good knowledge of some of these techniques, particularly searched after a experts in MAS solid-state NMR of polypeptides. S/he should have an interest in working in a highly interdisciplinary, international and collaborative environment. The project and position are funded by a three-year grant from the French National Agency for Research (ANR). The University of Strasbourg chemistry, life sciences and structural biology departments have excellent scientific records, with a multitude of collaborations world-wide.

Strasbourg is a very nice city on the French side of the Rhine river, at the border to Germany, with easy access to nearby mountains (Vosges, Black Forrest, Alps). Being in the heart of Europe it takes only short train rides to multiple destinations of scientific and/or touristic interest.
 
Candidates should send their CV, publication list and contact info for three references to:
 
Prof. Burkhard Bechinger,
bechinger@unistra.fr
Web Sites:
http://www-chimie.u-strasbg.fr/~rmnmc/
https://icfrc.fr/en/

 

 

 

 

 

 

 

 

 

 

 

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