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Job openings

    24 November 2020

    Postdoctoral Position in Electrophysiology, Salzburg

    Paracelsus Medical University Austria                                                         

    The Paracelsus Medical University is a privately operated university in Salzburg, Austria, with a secondary site in Nuremberg, Germany, and is oriented towards Health Sciences. The University offers education and research in human medicine, nursing sciences, and pharmacy.

    We also offer postgraduate doctorate degree study programs in medical science, molecular medicine,nursing & allied health sciences, as well as a number of university and further education programs. We have been committed to dynamiceducation and excellent researchsince 2003.

    The Institute of Anatomy and Cell Biology of Paracelsus Medical University, Salzburg, is offering a Post-doctoral position in electrophysiology. Fulltime (40hrs/week), starting at the earliest possible timepoint.The duration is currently limited to a two-year period.Remuneration is equivalent to personnelrates of the Austrian Science Fund (FWF),with gross annual salary of €54.453.

    In addition, we offer:
    Independent work within a novel research project sponsored by the Austrian National Bank (OeNB). Close connection to the University Clinics (Dep. of Cardiology).
    Good regional and international traffic connections.
    Qualified child care in immediate vicinity to the university-Cafeteriain immediate vicinity.
    Pleasant working atmosphere.

    Job specification:
    Youwill be required to independently conduct electrophysiological experiments (patch clamp) under various experimental conditions in human donor tissue.

    The aim of the study is a seminalelectrophysiological analysis and characterization of neurons in the choroid of the human eye.The project will be in cooperation with the electrophysiological research laboratory of the Department of Cardiology, Internal Medicine II, at the University Clinic Salzburg, Austria,and the Institute of Physiology of Paracelsus Medical University.

    Job requirements:
    The successful candidate will have a doctoral degree in life sciences or medical sciences. He/she will have experience in electrophysiology, and the ability to independently design and conduct patch clamp experiments. Expertise in immunohistochemistryand confocal microscopy is desired, but can otherwise be acquired on site.The written application should include a cover letter, curriculum vitae, all relevant certificates, letters of reference,and lists of completed scientific projects and publications (single pdf preferred).

    Please send your application to Mrs. Isabell Schimmel, Institute of Anatomy and Cell Biology (isabell.schimmel@pmu.ac.at).      

    Please note that due to organizational reasons, we cannot return your application documents; these will be deleted on completion of the process.

    The Paracelsus Medical University cannot reimburse any expenses related to the recruiting/application process, including travel expenses.

    Go to announcement
      24 November 2020

      Postdoctoral Scientist in Liège, Belgium

      Biophysical Investigation of SARS-CoV-2                                             


      University of Liège (Belgium)–Laboratory of Molecular Biophysics at Interfaces (Gembloux Agro-Bio Tech)Position open:Post-doctoral scientist (1-year contract) – biophysical investigation of the in vitro and in silicoanti-SARS-CoV-2 activity of microbial secondary metabolites. As part of an FNRS founded project (Exceptional Research Project 2020), the successful candidate will join  the Laboratory  of  Molecular  Biophysics  at  Interfaces (Drs Magali  Deleu  and  Laurence  Lins, Gembloux Agro-Bio Tech). The project has multidisciplinary aspects, since it gathers molecular biology (Pr M. Garigliani), synthetic biology (Pr P.Jacques) and molecular biophysics (Drs M. Deleu and L. Lins).

      Research description:
      During the lockdown the promoters of the projecthave started a collaboration to study the antiviral activity of microbial secondary metabolites on the SARS-CoV-2. They have identified a compound showing interesting activity but too high cytotoxicity.The main goals of the research are:-to decrypt the antiSARS-CoV-2 mode of action of different natural variants of these compounds, via in vitro, cellular and biophysicalapproaches and to unravel the structure-activity relationships;-based on the structure/activity relationships, to predict/select new derivatives of these microbial metabolite showing higher antiviral activity with less cytotoxicity. ProfilePost-doctoral scientist with experience in molecular biophysics (fluorescence spectroscopy, Infrared spectroscopy, isothermal titration calorimetry,...)  for the in vitroassays and molecular docking for the in silicopart of the project). Expertisein biophysics with liposomes would be valuable.Importantly, the candidate shall not have resided or carried out his/hermain activity (job, studies...) in Belgium for more than 24 months during the last 3 years.

      Candidates must have good working knowledge of English or French, a strong commitment to scientific research and an excellent academic record.Good communication skills and ability to work in a multidisciplinary team.Ability to organize and prioritize work duties.Start date 4th of January 2021.

      How to apply? Candidates  should  submit  an  application before 07th of December  2020 send  your  CV,  PhD certificate, motivation letter (with a brief summary of previous research activities), and names plus e-mail   addresses   of   referencesto    : Laurence    Lins   (l.lins@uliege.be) and Magali   Deleu (magali.deleu@uliege.be)
       

      Go to announcement
      • PostDoc
      17 November 2020

      PostDoc in experimental Biophysics

      Researcher for project in Czech Republic                                                                        

      The J.  Heyrovský  Instituteis  a  leading  and  prestigious  research  institution  in  the  Czech  Republic, known  worldwide  and  with  established  international  cooperation.  The  Institute  is  a  center  of fundamental research in physical chemistry and chemical physics, biophysics, theoretical chemistry and electrochemistry.

      The Department  of  Biophysical  Chemistry (group  of Prof.  Martin  Hof)  is  looking  for  a  researcher  to contribute to a new interesting project ondevelopment of supportedlipid bilayers, for a position asPostdoc in experimental BiophysicsA four  year  postdoctoral  position is  available  in  a  young, international  and creative  team  with  a collaborative atmosphere, in laboratories with leading-edge technology and equipment.The aim of the project is to develop protocols for formation of new tetheredlipid bilayersystems and to use themfor elucidating the role of aggregation in the function of membrane proteins. In addition tomembrane  biophysics,the  project  comprises  the  development  of  newoptical  microscopytechniques (fluorescence as well as labelfree)and liquid cell technology for electron microscopy. Theworkinvolves  collaboration  with national universities  and  groups  at University  of  Vienna, Leiden Universityand University of Göttingen.

      Start date: 1stJanuary2021

      Qualifications:
      PhD or equivalent degree in natural sciences (biophysics, physics, chemistry or related field).Good communication skills in written and spoken English. Familiarity withmembrane biophysics is an advantage.  We offerPosition for four years(01.2021 –12.2024)with a brutto salary of 89,500CZK(approx. 2550 Euronetto)plus yearly bonus, employee benefitpackage (e.g. contribution to culture, sport and children’s  activities;kindergarten;...)and flexible   working hours.   Travel   to   international collaborating groups and conferences.TheDepartment of Biophysical Chemistryhas a friendly atmosphereofinternational colleagueswithdiverse backgrounds(physics, chemistry, physical chemistry, biochemistry and biology). J. Heyrovský Instituteis  located in Prague,a  multicultural  city with a picturesque historical center full  of life and culture. For further information please contact Mariana Amaro at amaro@jh-inst.cas.cz.

      The J.  Heyrovský  Institute  iscommitted  to equality in  its  workforce  and  therefore  encourages applications fromallqualified individualsregardless of gender or otherpersonal background.Interested candidates can send your CV, PhD certificate, motivation letter (with a brief summary of previous research activities), and names plus e-mail addresses of references to email recruitment@jh-inst.cas.cz(contact person Dominika Patrovska) till 9 December 2020.

      Please, write in the subject line of your email SC2020_001.By submitting the application you confirm that all personal data you have sent to us are true.

      Go to announcement
      • PostDoc
      11 November 2020

      Open positions for physics PhD students and postdocs

      Open positions for physics PhD students and postdocs                                                                            

      The Stavans lab https://www.weizmann.ac.il/complex/stavans/home has openings for PhD students and postdocs interested in various topics that include Systems Biology, pattern formation, circadian clocks in multicellular organisms and bacterial communities from a physics standpoint.

      The lab is a highly interdisciplinary one, exposing members to a wide set of skills and techniques, including single-cell level fluorescence microscopy, sophisticated image analysis and mathematical modeling. The post-doctoral position is for 2 years with the possibility of renewal.

      The Weizmann Institute of Science is a premier institution of world renown, enjoying a thriving community of international students and postdocs.

      Some recent works from the lab include:
      Di Patti et al, PLoS Biol (2018)
      Tal et al PNAS (2014)

      Submit your application including cover letter (explaining background and motivation), CV and publication record via e-mail as one single PDF file to Prof. Joel Stavans (joel.stavans@weizmann.ac.il).

      Joel Stavans
      The Siegried and Irma Ullman Professorial Chair
      Department of Physics of Complex Systems
      Weizmann Institute of Science
      Rehovot 76100, Israel
      972-8-9342615

       

      Go to announcement
      • PostDoc
      11 November 2020

      Research Fellow in Chemical Biology

      Research Fellow in Chemical Biology                                                                  


      Are you an ambitious researcher looking for your next challenge? Do you have an established background in chemical biology in its broadest sense? Do you want to further your career in one of the UKs leading research intensive universities?
      As Research Fellow in Chemical Biology you will join a BBSRC-funded team focused on developing and exploiting new tools to understand and perturb protein-protein interactions (PPIs) involving intrinsically disordered regions. You will assist the Investigators in delivering this large research programme by focussing on the design and synthesis of small-molecule chemical probes for disease relevant PPIs, with considerable emphasis on targets in oncology.
      The post is associated with a major £5.4 million five-year collaborative research programme led by Professor Andy Wilson  https://wilson.leeds.ac.uk/, funded by the Biotechnology and Biological Sciences Research Council (BBSRC) https://bbsrc.ukri.org/, and bringing together the University of Leeds http://www.leeds.ac.uk/, the University of Oxford https://www.ox.ac.uk/, and project partners, AstraZeneca https://www.astrazeneca.co.uk/ and LifeArc https://www.lifearc.org/. This large and diverse programme focuses on Deciphering the function of intrinsically disordered protein regions in a cellular context using The Aurora A kinase (Aurora A) as a target. Aurora A represents a key potential target for anticancer therapeutics development and plays a fundamental role in regulating cell division.The specific purposes of the role are to (i) develop reagents capable of inhibiting the interactions of Aurora A, (ii) use proteomics methods to dissect the cellular interactome of Aurora A.
      You will be part of a large team based in The Wilson https://wilson.leeds.ac.uk/, and The Wright https://wright.leeds.ac.uk/ groups in the School of Chemistry https://eps.leeds.ac.uk/chemistry and the Astbury Centre for Structural Molecular Biology http://www.astbury.leeds.ac.uk/research/facilities.php with access to a superb infrastructure for research in chemical biology, including synthetic laboratories, NMR equipment, X-ray crystallographic, mass spectrometry and biophysical techniques, together with state of the art online resources.
      You will have a PhD (or have submitted your thesis prior to starting) in an area appropriate to the project, along with extensive knowledge of chemical proteomics and/or chemical probe development.
      Location:                            Leeds - Main Campus
      Faculty/Service:               Faculty of Engineering & Physical Sciences
      School/Institute:             School of Chemistry
      Category:                           Research
      Grade:                                Grade 7
      Salary:                                £33,797 to £40,322 p.a.
      Working Time:                37.5 hours per week
      Post Type:                         Full Time
      Contract Type:                Fixed Term (3 years due to grant funding)
      Closing Date:                    Sunday 22 November 2020
      Interview Date:               To be confirmed
      Reference:                         EPSCH1022
      Downloads:                      Candidate Brief  under https://jobs.leeds.ac.uk/Upload/vacancies/files/18783/EPSCH1022%20-Research%20Fellow%20in%20Chemical%20Biology.pdf
       
      You can apply online via: Research Fellow in Chemical Biology
      Are you an ambitious researcher looking for your next challenge? Do you have an established background in chemical biology in its broadest sense? Do you want to further your career in one of the UKs leading research intensive universities?
      As Research Fellow in Chemical Biology you will join a BBSRC-funded team focused on developing and exploiting new tools to understand and perturb protein-protein interactions (PPIs) involving intrinsically disordered regions. You will assist the Investigators in delivering this large research programme by focussing on the design and synthesis of small-molecule chemical probes for disease relevant PPIs, with considerable emphasis on targets in oncology.
      The post is associated with a major £5.4 million five-year collaborative research programme led by Professor Andy Wilson, funded by the Biotechnology and Biological Sciences Research Council (BBSRC), and bringing together the University of Leeds, the University of Oxford, and project partners, AstraZeneca and LifeArc. This large and diverse programme focuses on Deciphering the function of intrinsically disordered protein regions in a cellular context using The Aurora A kinase (Aurora A) as a target. Aurora A represents a key potential target for anticancer therapeutics development and plays a fundamental role in regulating cell division.The specific purposes of the role are to (i) develop reagents capable of inhibiting the interactions of Aurora A, (ii) use proteomics methods to dissect the cellular interactome of Aurora A.
      You will be part of a large team based in The Wilson, and The Wright groups in the School of Chemistry and the Astbury Centre for Structural Molecular Biology with access to a superb infrastructure for research in chemical biology, including synthetic laboratories, NMR equipment, X-ray crystallographic, mass spectrometry and biophysical techniques, together with state of the art online resources.
      You will have a PhD (or have submitted your thesis prior to starting) in an area appropriate to the project, along with extensive knowledge of chemical proteomics and/or chemical probe development.
      Location:                            Leeds - Main Campus
      Faculty/Service:               Faculty of Engineering & Physical Sciences
      School/Institute:             School of Chemistry
      Category:                           Research
      Grade:                                Grade 7
      Salary:                                £33,797 to £40,322 p.a.
      Working Time:                37.5 hours per week
      Post Type:                         Full Time
      Contract Type:                Fixed Term (3 years due to grant funding)
      Closing Date:                    Sunday 22 November 2020
      Interview Date:               To be confirmed
      Reference:                         EPSCH1022
      Downloads:                      Candidate Brief  
       
      You can apply online via: https://jobs.leeds.ac.uk/Vacancy.aspx?ref=EPSCH1022
      Are you an ambitious researcher looking for your next challenge? Do you have an established background in chemical biology in its broadest sense? Do you want to further your career in one of the UKs leading research intensive universities?
      As Research Fellow in Chemical Biology you will join a BBSRC-funded team focused on developing and exploiting new tools to understand and perturb protein-protein interactions (PPIs) involving intrinsically disordered regions. You will assist the Investigators in delivering this large research programme by focussing on the design and synthesis of small-molecule chemical probes for disease relevant PPIs, with considerable emphasis on targets in oncology.
      The post is associated with a major £5.4 million five-year collaborative research programme led by Professor Andy Wilson https://wilson.leeds.ac.uk/, funded by the Biotechnology and Biological Sciences Research Council (BBSRC), and bringing together the University of Leeds, the University of Oxford, and project partners, AstraZeneca and LifeArc. This large and diverse programme focuses on Deciphering the function of intrinsically disordered protein regions in a cellular context using The Aurora A kinase (Aurora A) as a target. Aurora A represents a key potential target for anticancer therapeutics development and plays a fundamental role in regulating cell division.The specific purposes of the role are to (i) develop reagents capable of inhibiting the interactions of Aurora A, (ii) use proteomics methods to dissect the cellular interactome of Aurora A.
      You will be part of a large team based in The Wilson, and The Wright groups in the School of Chemistry and the Astbury Centre for Structural Molecular Biology with access to a superb infrastructure for research in chemical biology, including synthetic laboratories, NMR equipment, X-ray crystallographic, mass spectrometry and biophysical techniques, together with state of the art online resources.
      You will have a PhD (or have submitted your thesis prior to starting) in an area appropriate to the project, along with extensive knowledge of chemical proteomics and/or chemical probe development.
      Location:                            Leeds - Main Campus
      Faculty/Service:               Faculty of Engineering & Physical Sciences
      School/Institute:             School of Chemistry
      Category:                           Research
      Grade:                                Grade 7
      Salary:                                £33,797 to £40,322 p.a.
      Working Time:                37.5 hours per week
      Post Type:                         Full Time
      Contract Type:                Fixed Term (3 years due to grant funding)
      Closing Date:                    Sunday 22 November 2020
      Interview Date:               To be confirmed
      Reference:                         EPSCH1022
      Downloads:                      Candidate Brief  
       
      You can apply online via: https://jobs.leeds.ac.uk/Vacancy.aspx?ref=EPSCH1022
      To explore the post further or for any queries you may have, please contact: Professor Andrew J Wilson, Professor of Organic Chemistry, School of Chemistry Tel: +44 (0)113 3431409 or email: a.j.wilson@leeds.ac.uk
       
      Prof Andy Wilson
      Royal Society Leverhulme Trust Senior Research Fellow
      Professor of Organic Chemistry
      Room G.15
      School of Chemistry and Astbury Centre for Structural Molecular Biology
      University of Leeds
      Woodhouse Lane
      Leeds LS2 9JT
      United Kingdom
      https://wilson.leeds.ac.uk/
      Office +44 (0)113 3431409
      Lab +44 (0)113 3436549 or 3436564
      Fax +44 (0)113 3436565
      https://wilson.leeds.ac.uk/
      http://www.poppi.website/
       

      To explore the post further or for any queries you may have, please contact: Professor Andrew J Wilson, Professor of Organic Chemistry, School of Chemistry Tel: +44 (0)113 3431409 or email: a.j.wilson@leeds.ac.uk
       
      Prof Andy Wilson
      Royal Society Leverhulme Trust Senior Research Fellow
      Professor of Organic Chemistry
      Room G.15
      School of Chemistry and Astbury Centre for Structural Molecular Biology
      University of Leeds
      Woodhouse Lane
      Leeds LS2 9JT
      United Kingdom
      A.J.Wilson@leeds.ac.uk
      Office +44 (0)113 3431409
      Lab +44 (0)113 3436549 or 3436564
      Fax +44 (0)113 3436565
      https://wilson.leeds.ac.uk/
      https://poppi.website/
       

      To explore the post further or for any queries you may have, please contact: Professor Andrew J Wilson, Professor of Organic Chemistry, School of Chemistry Tel: +44 (0)113 3431409 or email: a.j.wilson@leeds.ac.uk
       
      Prof Andy Wilson
      Royal Society Leverhulme Trust Senior Research Fellow
      Professor of Organic Chemistry
      Room G.15
      School of Chemistry and Astbury Centre for Structural Molecular Biology
      University of Leeds
      Woodhouse Lane
      Leeds LS2 9JT
      United Kingdom
      A.J.Wilson@leeds.ac.uk
      Office +44 (0)113 3431409
      Lab +44 (0)113 3436549 or 3436564
      Fax +44 (0)113 3436565
      https://wilson.leeds.ac.uk/
      http://www.poppi.website/

      Go to announcement
      • PhD
      11 November 2020

      Research Position, Grenoble, France

      Research Position, Grenoble, France                                  
       

      This is an informal message to advertise a permanent research position that will be available in the fall of 2021 for a computational researcher in the modeling group of the Chemistry and Biology of Metals Laboratory (https://www.cbm-lab.fr/en) at the CEA in Grenoble, France.

      Applicants’ principle research interest should be in the modeling and simulation of proteins and related systems using molecular mechanics, molecular dynamics, docking, homology modeling and related techniques. Experience with other methods (e.g. quantum chemistry, QM/MM) is welcome but not required.

      Researchers of all nationalities and levels of experience are encouraged to apply. There is an expectation that the successful applicant will take over the direction of the modeling group, either immediately or after a trial period of appropriate duration, depending on experience and familiarity with the French system.

      The formal procedure for application will be announced sometime in 2021.

      Requests for additional information should be sent to “martin.field@cea.fr”, “giulia.veronesi@cea.fr” or “yohann.moreau@cea.fr”.

      Martin Field.

      Adrian Mulholland                 Phone: +44-(0)117-928-9097
      Professor of Chemistry
      Centre for Computational Chemistry
      School of Chemistry               Fax:   +44-(0)117-925-0612
      University of Bristol             Adrian.Mulholland@bristol.ac.uk
      Bristol BS8 1TS             <http://www.chm.bris.ac.uk/pt/ajm/adrian.html>

      Chair, CCP-BioSim: the UK Collaborative Computational Project for Biomolecular Simulation <http://www.ccpbiosim.ac.uk>

      For questions relating to CCP-BioSIm, contact CCPBioSim Mailbox <ccp-biosim@bristol.ac.uk>

      For other queries, contact Manda Baynes <manda.baynes@bristol.ac.uk>

       

      Go to announcement
      • PostDoc
      11 November 2020

      Positions in Computational Biophysics, Finland

      Postdoc & PhD student positions in Computational Biophysics                                    


      Employer: Biological Physics group, University of Helsinki, Finland
      Contact: Prof. Ilpo Vattulainen (Ilpo.Vattulainen@helsinki.fi)
      Website: https://www.helsinki.fi/en/researchgroups/biophysics
      Posted: November 02, 2020
      Expires: Preferred deadline November 30, 2020, or until the positions have been filled.
      Job Description
      Two positions in computational biophysics / biological physics. The positions are for postdoctoral scientists
      and/or PhD students.
      Eligibility. Outstanding candidates with experience in computer simulations, and who have obtained PhD
      (postdoc positions) or MSc (PhD student positions) degrees in fields of biological (soft matter) physics,
      biophysics, (bio)physical chemistry, computational sciences, machine learning, and related fields including stat
      mech in stat physics are invited to apply. Experience with molecular dynamics simulations (with GROMACS,
      NAMD, etc.) and other simulation techniques (DFT, QM/MM, DPD, SRD, LB, etc.) on atomistic and coarsegrained
      levels is considered as an asset.
      Working Environment. The postdocs and PhD students will be part of the Biological Physics group directed by
      Ilpo Vattulainen. The group has ~20 members. The group specializes in multi-scale simulations using a wide
      arsenal of techniques ranging from QM to atomistic and coarse-grained simulations. Collaborations with
      experimental and theoretical teams are strong. The work environment is relaxed and the successful candidate
      will have an opportunity to influence the project content. The group has been granted funding by, e.g., ERC,
      Academy of Finland Center of Excellence scheme, Human Frontier Science Program, EU, etc.
      Funding for the Positions. The gross salary will be about 3500-
      4000 EUR/month for postdocs, and about 2300-3000
      EUR/month for PhD students depending on experience.
      Project. The projects will focus on membrane-associated
      receptors / proteins with an objective to understand how their
      dynamics and activation are modulated, and how impairment of
      these modulation mechanisms compromises the function. The
      proteins in question are involved in abundant diseases. The
      research is strongly coupled to collaborations with several firstclass
      experimental teams. Detailed project description will be given during the interviews.
      Computing Resources. The successful candidates will have access to quite outstanding computing resources in
      the national supercomputing center (www.csc.fi, about 7 petaflops) and in the pre-exascale computing center
      LUMI (https://www.lumi-supercomputer.eu/, 200 petaflops).
      Contact. Further information can be obtained from Ilpo Vattulainen (Ilpo.Vattulainen@helsinki.fi).
      Application Procedure. Applications must be sent in the PDF format, and must include CV, list of publications,
      description of research interests, and names of 3 people willing to provide a letter of recommendation.
      Application including all this material should be sent to Vattulainen as a single PDF file. Recommendation
      letters are not crucial at this stage but may of course be sent separately.
      Deadline. Applications are considered until the positions have been filled. Applicants who are short-listed for
      the positions will be contacted personally.
      Examples of Recent Papers Published by our Group:
      • S. Wilmes et al., Science 367, 643 (2020).
      • T. Gutmann et al., Journal of Cell Biology 219, e201907210 (2020).
      • R. Paananen et al., The Journal of Physical Chemistry Letters 10, 3893 (2019).
      • S. Li et al., Nature Methods 16, 866 (2019).
      • G. Enkavi et al., Chemical Reviews 119, 5607 (2019).
      • T. Pantsar et al., PLoS Computational Biology 14, e1006458 (2018).
      • M. Manna et al., eLife 5, e18432 (2016).
      • K. Kaszuba et al., PNAS 112, 4334 (2015).
      COVID-19. In these difficult times, it is justified to emphasize that Finland is one of the safest countries worldwide.
      Finland is also generally a very safe country to live in, including an excellent health care system. We enjoy
      Finland's beautiful nature and the cleanest air in the world. Helsinki is an international city with very good
      services for families and children. Everyone in our group has the right to telecommute.

      Go to announcement
      • PhD
      11 November 2020

      Biomolecular Simulation PhD Studentships in Bristol

      two PhD studentship projects
       
      I have two PhD studentship project available in the area of computational enzymology, to start in Sept/Oct 2021. Both are through competition-funded doctoral training programmes. The projects will primarily involve QM/MM and molecular dynamics simulations (incl. free energy calculations) and some experimental work (enzyme kinetics, possible structural biology).
      The students will benefit from access to the BlueCrystal High-Performance Computing clusters in Bristol (> 800 TFLOPS), as well as a vibrant collaborative environment with excellent computational chemistry and experimental groups in Bristol and beyond.
       
      Project 1: Simulation-led investigation and engineering of enzymes involved in abyssomicin antibiotic biosynthesis
      SWBio Doctoral Training Programme 4 year PhD project
      Co-supervisors: Paul Race (Biochemistry, Bristol), Chris Willis (Chemistry, Bristol), Martin Hayes (AstraZeneca)
       
      Enzymes are remarkable biocatalysts that can be used in industry for sustainable production of complex molecules. In this project, enzymes involved in the production of abyssomicin antibiotics will be investigated using biomolecular simulation (docking, molecular dynamics, QM/MM reaction simulations) and some wet-lab experiments. A particular focus will be on enzymes that catalyse the Diels-Alder reaction, a [4+2] cycloaddition reaction commonly employed in the synthesis of bioactive natural products, including important pharmaceuticals. Computational protocols to predict enzyme variants with desirable properties will be developed and then improved through experimental characterisation of promising enzyme variants (product outcome, kinetics and structural biology). You will be part of a successful collaborative team in Bristol (linked to the BioDesign Institute). By working with our industrial partner AstraZeneca, the impact of engineered enzymes for pharmaceutical drug discovery can be realised.
       
      Details on FindAPhD.com: https://www.findaphd.com/phds/project/simulation-led-investigation-and-engineering-of-enzymes-involved-in-abyssomicin-antibiotic-biosynthesis/?p124765
      Application deadline: Dec 7th
      Full funding is available for UK & UK-based EU students only, see SWBio website for details.
       
       
      Project 2: Countering antimicrobial resistance: investigating β-lactamase inhibitors using atomistic simulation and experiment
      GW4 Biomed Doctoral Training Programme 3.5 year PhD project
      Co-supervisors: Jim Spencer, Adrian Mulholland
       
      Antibiotic resistance threatens human health. β-lactamases are the main culprit in conferring resistance to β-lactam antibiotics. Their action can be countered with inhibitors, some of which may also halt bacterial growth, whereas others don’t. We will investigate these differences by simulation and experiment, develop simulation protocols to predict inhibitor activity, and use these to guide inhibitor design.
       
      Details on FindAPhD.com: https://www.findaphd.com/phds/project/countering-antimicrobial-resistance-investigating-lactamase-inhibitors-using-atomistic-simulation-and-experiment/?p114533
      Applications close Nov 23rd, but please contact Marc before applying to the DTP (by November 10th), with a draft application form.
       
      See the information on eligibility (https://www.gw4biomed.ac.uk/eligibility/) and how to apply:  https://www.gw4biomed.ac.uk/doctoral-students/
       
       
      For both positions, you will need to compete with other applicants, including those that apply to other DTP projects, for the available funding. You will stand the best chance with a good (predicted) first degree (1 or 2:1), and/or (relevant) MSc experience.
       
      For more information, don't hesitate to contact me: marc.vanderkamp@bristol.ac.uk and/or please visit https://vanderkampgroup.wordpress.com
       
       
       
      Dr. Marc W. van der Kamp
      BBSRC David Phillips Research Fellow & Senior Lecturer
      School of Biochemistry
      Faculty of Biomedical Sciences
      & Centre for Computational Chemistry, School of Chemistry
      University of Bristol
      Biomedical Sciences building
      University Walk
      Bristol BS8 1TD
      Tel: +44 117 3312147 (office)
      Marc.vanderKamp@bristol.ac.uk

      Website: https://vanderkampgroup.wordpress.com/
      Twitter: @marcvanderkamp

      Go to announcement
      • PostDoc
      21 October 2020

      UBC Dept of Chem - Biological Chemistry/Chemical Biology

      theoretical and computational biophysics of membranes

       

      A two-year postdoctoral position in theoretical and computational biophysics of membranes and membrane proteins is available at PHYLIFE: Centre for Physical Lifesciences (formerly MEMPHYS: Centre for Biomembrane Physics) at the University of Southern Denmark (SDU), Odense. The candidate will be supervised by Associate Professor Himanshu Khandelia https://hkgroup.sdu.dk/  and will work in a highly collaborative atmosphere together with theorists and experimental scientists. 

      Starting date: 1 December 2020 or ASAP. Application deadline: 27 October 2020.

      The project revolves around implementing molecular simulations of novel voltage-sensing elements in ion channels and ion pumps. The selected candidate will collaborate with experimental groups at SDU, University of Aarhus and the University of Texas Medical Centre. There is a possibility to spend some time in experimental laboratories. 
      #############


      Application portal: https://www.sdu.dk/en/service/ledige_stillinger/1128386

      -----------------------------------------------

      Himanshu Khandelia
      Associate Professor
      MEMPHYS: Center for Biomembrane Physics
      Department of Physics, Chemistry and Pharmacy (FKF)
      University of Southern Denmark (SDU)
      hkhandel@sdu.dk 
      +4565503510
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        29 September 2020

        PhD Student or Postdoc (f/m/d)

        The Max Planck Institute for Biophysical Chemistry

        is one of the largest institutes of the Max Planck Society for the Advancement of Science and conducts basic research to advance knowledge and benefit society. Innovative projects and interdisciplinary cooperation characterize research within the Max Planck Society. The Department of Theoretical and Computational Biophysics (Prof. Dr. Helmut Grubmüller) invites applications for a position as

        PhD Student or Postdoc (f/m/d) (Code number 19-20) for the projects – Ribosomal Translation: Molecular Mechanisms and Antibiotics – – Statistical Mechanics and Function of Intrinsically Disordered Proteins – – Optimal Free Energy and Entropy Calculations – – Markovian Free Energy Models of F-ATP Synthase Function – – Fast Multipole Based Constant pH Methods –

        The successful candidate for either position has a keen interest and strong skills in computational biomolecular physics, skills in structural biology, statistical mechanics, and scientific computing, and a strong interest in interdisciplinary research and collaboration with experimental groups. PhD candidates hold (or expect to complete soon) a Masters or equivalent degree; Postdocs hold a PhD or equivalent degree in any of these or a related field. PhD students will have the opportunity to participate in one of several available PhD programs, with four years funding, in collaboration with the University of Göttingen. Masters students aiming at a fast track PhD are also welcome. The Postdoc position is limited to two years with a possibility of extension. Payment and benefits are based on the TVöD guidelines. The starting date is flexible. The group language is English, so no German language skills are required – but it’s a great opportunity for you to learn German!

        The Max Planck Society is committed to increasing the number of individuals with disabilities in its workforce and therefore encourages applications from such qualified individuals.

        Interested? Submit your application including cover letter (explaining background and motivation), CV, transcripts, and publication record preferably via e-mail as one single PDF file to

        ausschreibung19-20@mpibpc.mpg.de
        Max Planck Institute for Biophysical Chemistry
        Department „Theoretical and Computational Biophysics“
        Prof. Dr. Helmut Grubmüller
        Am Fassberg 11
        37077 Göttingen Germany
        Web: https://www.mpibpc.mpg.de/grubmueller

         

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